68Ga-DOTATATE PET/CT Compared with 131I-MIBG SPECT/CT in the Evaluation of Neural Crest Tumors

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Shahrokhi Pezhman; EMAMI ARDEKANI ALIREZA; HARSINI SARA; EFTEKHARI MOHAMMAD; FARD ESFAHANI ARMAGHAN; FALLAHI BABAK; KARAMZADE ZIARATI NAJME; AKHLAGHI MEHDI; FARZANEFAR SAEED; Pejman Hashemi Taheri Amir; BEIKI DAVOOD

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Journal: Asia Oceania Journal of Nuclear Medicine & Biology Year:2020 | Volume:8 | Issue:1 Page(s): 8-17

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Title

68Ga-DOTATATE PET/CT Compared with 131I-MIBG SPECT/CT in the Evaluation of Neural Crest Tumors

Author(s)

Keywords

68Ga

DOTATATE 131I

MIBG PET/CT Neural crest tumors

Abstract

Objective(s): 68Ga-DOTATATE positron emission tomography (PET)/computed tomography (CT) has shown promising results in imaging of neural crest tumors (NCT). Herein, we compared the performance of 68Ga-DOTATATE PET/CT and 131I-MIBG single photon emission computed tomography (SPECT)/CT in the initial diagnosis, staging and follow-up of patients with NCTs. Methods: Twenty-five patients (males: females=8: 17; age range=2– 71 years) with clinically proven or suspicious neuroblastoma, pheochromocytoma (PCC) or paraganglioma (PGL) were enrolled in this prospective study and underwent both 68Ga-DOTATATE PET/CT and 131I-MIBG SPECT/CT. A composite reference standard derived from histopathological information, together with anatomical and functional imaging findings, was used to validate the results. Imaging findings were assessed on a per-patient and on a per-lesion basis. Sensitivity and accuracy were assessed using McNemar’ s test. Results: Referring to radiological imaging and histopathological findings as reference standard, 68Ga-DOTATATE and 131I-MIBG scans showed a sensitivity and accuracy of (100%, 96%) and (86. 7%, 88%), respectively, on a per-patient basis. In PCC/PGL patients, on a per-patient basis, the sensitivity of 68Ga-DOTATATE was 100% and that of 131I-MIBG was 77. 8%. In neuroblastoma patients, on a per-patient basis, the sensitivities of both 68Ga-DOTATATE and 131I-MIBG were 100%. Overall, in this patient cohort, 68Ga-DOTATATE PET/CT identified 52 lesions and 131I-MIBG SPECT/CT identified only 30 lesions. On a per-lesion analysis, 68Ga-DOTATATE was found to be superior to 131I-MIBG in detecting lesions in all anatomical locations, particularly osseous lesions. According to the McNemar test results, differences were not statistically significant. Conclusion: This relatively small patient cohort suggests 68Ga-DOTATATE PET/CT be superior to 131I-MIBG SPECT/CT in providing particularly valuable information for both primary staging and follow-up in patients with NCT.

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References

Comparison of the 68Ga-DOTATATA PET/CT, FDG PET/CT, and MIBG SPECT/CT in the evaluation of suspected primary pheochromocytomas and paragangliomas

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APA: Copy

Shahrokhi, Pezhman, EMAMI ARDEKANI, ALIREZA, HARSINI, SARA, EFTEKHARI, MOHAMMAD, FARD ESFAHANI, ARMAGHAN, FALLAHI, BABAK, KARAMZADE ZIARATI, NAJME, AKHLAGHI, MEHDI, FARZANEFAR, SAEED, Pejman Hashemi Taheri, Amir, & BEIKI, DAVOOD. (2020). 68Ga-DOTATATE PET/CT Compared with 131I-MIBG SPECT/CT in the Evaluation of Neural Crest Tumors. ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY, 8(1), 8-17. SID. https://sid.ir/paper/764787/en

Vancouver: Copy

Shahrokhi Pezhman, EMAMI ARDEKANI ALIREZA, HARSINI SARA, EFTEKHARI MOHAMMAD, FARD ESFAHANI ARMAGHAN, FALLAHI BABAK, KARAMZADE ZIARATI NAJME, AKHLAGHI MEHDI, FARZANEFAR SAEED, Pejman Hashemi Taheri Amir, BEIKI DAVOOD. 68Ga-DOTATATE PET/CT Compared with 131I-MIBG SPECT/CT in the Evaluation of Neural Crest Tumors. ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY[Internet]. 2020;8(1):8-17. Available from: https://sid.ir/paper/764787/en

IEEE: Copy

Pezhman Shahrokhi, ALIREZA EMAMI ARDEKANI, SARA HARSINI, MOHAMMAD EFTEKHARI, ARMAGHAN FARD ESFAHANI, BABAK FALLAHI, NAJME KARAMZADE ZIARATI, MEHDI AKHLAGHI, SAEED FARZANEFAR, Amir Pejman Hashemi Taheri, and DAVOOD BEIKI, “68Ga-DOTATATE PET/CT Compared with 131I-MIBG SPECT/CT in the Evaluation of Neural Crest Tumors,” ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY, vol. 8, no. 1, pp. 8–17, 2020, [Online]. Available: https://sid.ir/paper/764787/en

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