Prevalence of Castration Success Rate in Iranian Metastatic Prostate Cancer Patients: A Referral Center Statistics

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ALLAMEH FARZAD; RAHAVIAN AMIRHOSSEIN; Ghiasy Saleh

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Journal: International Journal of Cancer Management Year:2018 | Volume:11 | Issue:10 Page(s): 0-0

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Title

Prevalence of Castration Success Rate in Iranian Metastatic Prostate Cancer Patients: A Referral Center Statistics

Author(s)

ALLAMEH FARZAD | RAHAVIAN AMIRHOSSEIN | Ghiasy Saleh | Issue Writer Certificate

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Abstract

Dear Editor, Prostate cancer (PC) is the most common malignancy in men (1, 2). Choosing the appropriate treatment is important, especially in metastatic PC (3), and one of the treatments that is used, is luteinizing hormone-releasing hormone (LH-RH) agonist drugs that cause hormonal castration and tumor deprivation (4). But, in some cases, patients do not respond to this drugs and the level of testosterone failed to drop. In these cases, we require the use of other treatments (5, 6). In this prospective study, after the approval of Ethics Committee was obtained, 36 patients with mean age of 71. 86 ± 7. 25 years (minimum 58 years and maximum 84 years), who were referred to Shohada-e-Tajrish Hospital, Tehran, Iran, were treated with LH-RH agonist (Diphereline® 3. 75 mg IPSEN company) for 3 months. Serum prostate-specific antigen (PSA) and testosterone levels were evaluated in the two phases including before and 3 months after treatment; then, the frequency of the participants with testosterone level above 20 ng/dL (castration not achieved) were determined and reported based on the age and location of the metastasis. Mean testosterone concentrations in the morning before and 3 months after starting hormone therapy were 362. 94 ± 141. 9 ng/dL and 12. 21 ± 10. 97 ng/dL, respectively, which was significantly decreased. The mean PSA level before and 3 months after the start of treatment was 20. 68 ± 12. 18 ng/mL and 6. 29 ± 6. 2 ng/mL, respectively. In two cases (5. 6%), the PSA level was not less than 50% of the baseline 3 months after starting the treatment, and in 4 cases (11. 1%), testosterone level did not drop to less than 20 ng/dL (castration not achieved). All four patients that have been considered as "castration not achieved" have been associated with multiple metastases. Three cases (75%) of these patients had visceral metastasis. It was found that the success in castration was significantly correlated with location of the metastasis (P = 0. 001) and there was no correlation with age and number of metastases.

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APA: Copy

ALLAMEH, FARZAD, RAHAVIAN, AMIRHOSSEIN, & Ghiasy, Saleh. (2018). Prevalence of Castration Success Rate in Iranian Metastatic Prostate Cancer Patients: A Referral Center Statistics. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), 11(10), 0-0. SID. https://sid.ir/paper/765013/en

Vancouver: Copy

ALLAMEH FARZAD, RAHAVIAN AMIRHOSSEIN, Ghiasy Saleh. Prevalence of Castration Success Rate in Iranian Metastatic Prostate Cancer Patients: A Referral Center Statistics. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION)[Internet]. 2018;11(10):0-0. Available from: https://sid.ir/paper/765013/en

IEEE: Copy

FARZAD ALLAMEH, AMIRHOSSEIN RAHAVIAN, and Saleh Ghiasy, “Prevalence of Castration Success Rate in Iranian Metastatic Prostate Cancer Patients: A Referral Center Statistics,” INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), vol. 11, no. 10, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/765013/en

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