Genetically modified mice-Methods, applications and outlook

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Eskandarian Boroujeni m.; ALIZADEH R.; Afkhami f.; TAVAKOL Z.; SHAMSARA M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES Year:2019 | Volume:24 | Issue:1 (99) Page(s): 24-44

Download Full-Text

Persian Verion

View:

1,427

Download:

Cites:

Information Journal Paper

Title

Genetically modified mice-Methods, applications and outlook

Author(s)

Keywords

Transgenic miceQ1

Functional geneticsQ1

Genes targetingQ1

Homologous recombinationQ1

Abstract

Background & Aim: Transgenic mice, of tengenerated by random integration of foreign genes into the mouse genome or by targeted mutation in a particular gene, have demonstrated to be a very effective tool for studying gene function in living things. In this review article, we discussed on the current methods of generating genetically-modified mice and their related problems and then investigated the new methods developed to overcome these problems. Finally, we discussed future prospects on the gene targeting. Methods & Materials: This is a review article, which has been written after searching Pubmed, Scopus, Google Scholar, Springer, Elsevier and Magiran databases by using keywords of Transgenic mice, Functional genetics, genetargeting, and Homologous recombination. Results: This study dealt with genetic variations in a wide range, differential processing and inactivation of gene-specific isoforms, local and induced genetic changes, Cre/loxP system and some future perspectives. Conclusion: Success rate in genetic modification of mouse genome has increased dramatically, and use of knockout mice has resulted in increased knowledge of human biology and diseases.

Cites

No record.

References

No record.

Cite

APA: Copy

Eskandarian Boroujeni, m., ALIZADEH, R., Afkhami, f., TAVAKOL, Z., & SHAMSARA, M.. (2019). Genetically modified mice-Methods, applications and outlook. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 24(1 (99) ), 24-44. SID. https://sid.ir/paper/76526/en

Vancouver: Copy

Eskandarian Boroujeni m., ALIZADEH R., Afkhami f., TAVAKOL Z., SHAMSARA M.. Genetically modified mice-Methods, applications and outlook. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;24(1 (99) ):24-44. Available from: https://sid.ir/paper/76526/en

IEEE: Copy

m. Eskandarian Boroujeni, R. ALIZADEH, f. Afkhami, Z. TAVAKOL, and M. SHAMSARA, “Genetically modified mice-Methods, applications and outlook,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 1 (99) , pp. 24–44, 2019, [Online]. Available: https://sid.ir/paper/76526/en

Related Journal Papers