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Information Journal Paper

Title

Effects of Alpha-Lipoic Acid on TGF- 1 and Urotensin-II Levels in Glucocorticoid-Induced Osteonecrosis in Rats

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Abstract

 Background: Osteonecrosis (ON) is a serious health problem, which dramatically reduces the quality of life. Objectives: In the present study on the rat model of glucocorticoids (GCs)-induced ON, we explored the influence of Alpha-Lipoic Acid on serum levels of TGF- 1 and Urotensin-II (U-II) and on histological alteration with respect to fatty degeneration and osteocyte necrosis. Methods: A total of 32 male Wistar albino rats were equally assigned to four groups, including control, methylprednisolone acetate (MPA), Alpha-Lipoic Acid (ALA), and MPA with ALA (MP1 + ALA). The animals in MPA group subcutaneously received 15 mg/kg/week during 2 weeks, whereas 100 mg/kg/day ALA was intraperitoneally administered to ALA group during 4 weeks. The MPA + ALA group had both treatments with the same doses. ON was confirmed and graded histologically. Lipid peroxidation and DNA damage levels were immunohistochemically assessed in rats’ bones. Results: After histopathological examinations, ALA injection attenuated oxidative stress levels through reducing both 8-OHdG-and 4-HNE-positive cells in the femoral head region (P < 0. 05). The U-II and TGF- 1 protein levels significantly decreased after ALA treatment in MPA injected animals (P < 0. 05, P < 0. 01, respectively). Moreover, there was a strong correlation between U-II and TGF- 1 protein levels (P = 0. 019, r = 0. 884). Conclusions: This study is novel with regard to showing the therapeutic effects of ALA on GC-inducedONin rats as well as the strong correlation between the expression levels of U-II and TGF- 1 proteins. In this regard, ALAmaybe a therapeutic agent in the treatment of ON patients.

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    APA: Copy

    Koca, Irfan, DOKUYUCU, RECEP, Tas, Zeynel Abidin, Gokce, Hasan, & Ozcan, Oguzhan. (2020). Effects of Alpha-Lipoic Acid on TGF- 1 and Urotensin-II Levels in Glucocorticoid-Induced Osteonecrosis in Rats. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 22(4), 0-0. SID. https://sid.ir/paper/766027/en

    Vancouver: Copy

    Koca Irfan, DOKUYUCU RECEP, Tas Zeynel Abidin, Gokce Hasan, Ozcan Oguzhan. Effects of Alpha-Lipoic Acid on TGF- 1 and Urotensin-II Levels in Glucocorticoid-Induced Osteonecrosis in Rats. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2020;22(4):0-0. Available from: https://sid.ir/paper/766027/en

    IEEE: Copy

    Irfan Koca, RECEP DOKUYUCU, Zeynel Abidin Tas, Hasan Gokce, and Oguzhan Ozcan, “Effects of Alpha-Lipoic Acid on TGF- 1 and Urotensin-II Levels in Glucocorticoid-Induced Osteonecrosis in Rats,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 22, no. 4, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/766027/en

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