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Information Journal Paper

Title

Effect of Nortriptyline on Spreading Depolarization

Pages

  0-0

Abstract

 Background: Spreading Depolarization is associated with the extension of lesion size and complications in some important neurological diseases such as Stroke, Epilepsy, Migraine, and Traumatic Brain Injury. Objectives: This study aimed to reveal some molecular aspects of Spreading Depolarization and suggesting new therapeutic targets for its control by changing the function of different astrocytic and neuronal ion channels. Methods: The effects of Nortriptyline on Spreading Depolarization in cortical and hippocampal tissues and on the electrophysiological properties of CA1 hippocampal pyramidal neurons were assessed by extra-and intracellular recording, following washing rat brain slices by the drug. Results: Nortriptylinemadea significant increase in the amplitude of Spreading Depolarization in corticalandhippocampal tissues relative to control but did not change the duration significantly in each of the tissues. No significant difference was found in the effects of Spreading Depolarization on the electrophysiological properties of the CA1 pyramidal neurons between Nortriptyline and control groups. Conclusions: The stimulating effect of Nortriptyline on Spreading Depolarization is probably related to the augmentation of extracellular potassium collection in the cortex and hippocampus due to inhibition of astrocytic potassium scavenging function. This change can make more neurons prone to depolarization and increase the overall amplitude of Spreading Depolarization waves. Further studies should assess the effect of enhancing the clearance function of astrocyte-specific inwardly rectifying potassium channels, Kir4. 1, or preventing other factors contributing to Spreading Depolarization on control of the process.

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    APA: Copy

    BEHZAD, EBRAHIM, GHABAEE, MOJDEH, BIGDELI, MOHAMMAD REZA, Noorbakhsh, Farshid, & GORJI, ALI. (2020). Effect of Nortriptyline on Spreading Depolarization. ARCHIVES OF NEUROSCIENCE, 7(3), 0-0. SID. https://sid.ir/paper/766767/en

    Vancouver: Copy

    BEHZAD EBRAHIM, GHABAEE MOJDEH, BIGDELI MOHAMMAD REZA, Noorbakhsh Farshid, GORJI ALI. Effect of Nortriptyline on Spreading Depolarization. ARCHIVES OF NEUROSCIENCE[Internet]. 2020;7(3):0-0. Available from: https://sid.ir/paper/766767/en

    IEEE: Copy

    EBRAHIM BEHZAD, MOJDEH GHABAEE, MOHAMMAD REZA BIGDELI, Farshid Noorbakhsh, and ALI GORJI, “Effect of Nortriptyline on Spreading Depolarization,” ARCHIVES OF NEUROSCIENCE, vol. 7, no. 3, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/766767/en

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