Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

124
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

102
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Anti-inflammatory effect of Adiantum capillus-veneris hydroalcoholic and aqueous extracts on acetic acid-induced colitis in rats

Pages

  492-503

Abstract

 Objective: Colitis is an inflammatory bowel disease with unknown etiology where many factors might play a role. Adiantum capillus-veneris may have beneficial effects in colitis because of its anti-inflammatory, antioxidant, wound healing and antimicrobial effects. The aim of this study was to explore the anti-inflammatory and anti-ulcerative effects of A. capillus-veneris on acetic acid-induced colitis in a rat model. Materials and Methods: A. capillus-veneris aqueous (ACAE; 150, 300, and 600 mg/kg) and hydroalcoholic extract (ACHE; 150, 300, and 600 mg/kg) were given orally (p. o. ) to male Wistar rats 2 hr before induction of colitis by intra-rectal administration of acetic acid 3%, and continued for 4 days. Prednisolone (4 mg/kg) and mesalazine (100 mg/kg) were applied p. o., as reference drugs for comparison. On day five, colitis indices of tissue specimens were evaluated and levels of biochemical markers including myeloperoxidase (MPO) and malondialdehyde (MDA) were determined. Results: In all groups treated with ACAE and ACHE with the exception of ACAE (150 mg/kg), ulcer index and wet weight of colon as parameters of macroscopic injuries, total colitis index as marker of microscopic features and MPO activity were significantly reduced in comparison to the control group; however, MDA value was only diminished in ACAE (300 and 600 mg/kg) and ACHE (300 mg/kg) groups significantly. Conclusion: This research showed that ACAE and ACHE had dose-related beneficial effects on acetic acid-induced colitis and these effects could be attributed to anti-inflammatory, ulcer healing and antioxidant activities of these extracts.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Khoramian, Ladan, SAJJADI, SEYED EBRAHIM, & MINAIYAN, MOHSEN. (2020). Anti-inflammatory effect of Adiantum capillus-veneris hydroalcoholic and aqueous extracts on acetic acid-induced colitis in rats. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 10(5), 492-503. SID. https://sid.ir/paper/766885/en

    Vancouver: Copy

    Khoramian Ladan, SAJJADI SEYED EBRAHIM, MINAIYAN MOHSEN. Anti-inflammatory effect of Adiantum capillus-veneris hydroalcoholic and aqueous extracts on acetic acid-induced colitis in rats. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2020;10(5):492-503. Available from: https://sid.ir/paper/766885/en

    IEEE: Copy

    Ladan Khoramian, SEYED EBRAHIM SAJJADI, and MOHSEN MINAIYAN, “Anti-inflammatory effect of Adiantum capillus-veneris hydroalcoholic and aqueous extracts on acetic acid-induced colitis in rats,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 10, no. 5, pp. 492–503, 2020, [Online]. Available: https://sid.ir/paper/766885/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top