مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

WOUND HEALING ACTIVITY OF EXTRACTS AND FORMULATIONS OF ALOE VERA, HENNA, ADIANTUM CAPILLUS‑VENERIS, AND MYRRH ON MOUSE DERMAL FIBROBLAST CELLS

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Abstract

 Background: Among the most important factors in WOUND HEALING pathways are transforming growth factor beta1 and VASCULAR ENDOTHELIAL GROWTH FACTOR. FIBROBLASTs are the main cell in all phases wound closure. In this study, the extracts of plant materials such as Adiantum capillus‑veneris, Commiphora molmol, Aloe vera, and henna and one mixture of them were used to treatment of normal mouse skin FIBROBLASTs.Methods: Cytotoxic effects of each extract and their mixture were assessed on mouse skin FIBROBLASTs cells using 3‑ (4, 5‑dimethylthiazol‑2‑yl) ‑2, 5‑diphenyltetrazolium bromide assay. We performed migration assays to assess migration properties of mouse skin FIBROBLASTs cells in response to the extracts. Changes in the gene expression of the Tgf b1and Vegf‑A genes were monitored by real‑time polymerase chain reaction.Results: A. capillus‑veneris, C. molmol and henna extract improved the expression of Tgf b1 gene. All used extracts upregulated the expression of Vegf‑A gene and promoted the migration of mouse FIBROBLAST cells in vitro.Conclusions: The present study demonstrated that the mentioned HERBAL extracts might be effective in WOUND HEALING, through the improvement in the migration of FIBROBLAST cells and regulating the gene expression of Tgf b1and Vegf‑A genes in FIBROBLAST cells treated with extracts.

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    APA: Copy

    Negahdari, Samira, GALEHDARI, HAMID, KESMATI, MAHNAZ, REZAIE, ANAHITA, & SHARIATI, GHOLAMREZA. (2017). WOUND HEALING ACTIVITY OF EXTRACTS AND FORMULATIONS OF ALOE VERA, HENNA, ADIANTUM CAPILLUS?VENERIS, AND MYRRH ON MOUSE DERMAL FIBROBLAST CELLS. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 8(-), 0-0. SID. https://sid.ir/paper/316512/en

    Vancouver: Copy

    Negahdari Samira, GALEHDARI HAMID, KESMATI MAHNAZ, REZAIE ANAHITA, SHARIATI GHOLAMREZA. WOUND HEALING ACTIVITY OF EXTRACTS AND FORMULATIONS OF ALOE VERA, HENNA, ADIANTUM CAPILLUS?VENERIS, AND MYRRH ON MOUSE DERMAL FIBROBLAST CELLS. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE[Internet]. 2017;8(-):0-0. Available from: https://sid.ir/paper/316512/en

    IEEE: Copy

    Samira Negahdari, HAMID GALEHDARI, MAHNAZ KESMATI, ANAHITA REZAIE, and GHOLAMREZA SHARIATI, “WOUND HEALING ACTIVITY OF EXTRACTS AND FORMULATIONS OF ALOE VERA, HENNA, ADIANTUM CAPILLUS?VENERIS, AND MYRRH ON MOUSE DERMAL FIBROBLAST CELLS,” INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, vol. 8, no. -, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/316512/en

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