Correlates and Prognostic Value of NT-proBNP in Post-Acute Coronary Syndrome Patients with Preserved Left Ventricular Ejection Fraction

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Fontes Oliveira Marta; Martins Filipe; GOMES LUISA; Trepa Maria; Baggen Santos Raquel; Costa Ricardo; Rodrigues Patricia; Luz Andre; Cabral Sofia; Santos Mario; Torres Severo

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Journal: INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL Year:2019 | Volume:13 | Issue:4 Page(s): 127-132

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Title

Correlates and Prognostic Value of NT-proBNP in Post-Acute Coronary Syndrome Patients with Preserved Left Ventricular Ejection Fraction

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Keywords

Prognosis NT

proBNP Myocardial Infarction

Abstract

Background: Patients with Acute Coronary Syndrome (ACS) with preserved Left Ventricular Ejection Fraction (LVEF) have an incidence of adverse outcomes despite the previously presumed benign prognosis. Objective: We hypothesized that NT-pro-BNP could help refine the risk stratification of these patients. Methods: In this observational retrospective study, laboratory and clinical data were collected from 232 consecutive patients with ACS and preserved LVEF (> 50%) and no previous history of Heart Failure (HF) at hospital discharge. Associations between NTproBNP and the composite outcome of HF hospitalization, HF diagnosis de novo, and all-cause mortality were assessed by univariate and multivariable Cox models. Statistical analyses were performed using Stata software, version 12. 1 and a two-sided P-value < 0. 05 was considered to be statistically significant. Results: The NT-proBNP median was 408 [IQR 177-853] pg/mL. Patients with increased NT-proBNP were older and were more likely to be female (P = 0. 013), be non-smoker (P = 0. 039), have worse renal function (P < 0. 001), and have lower hemoglobin concentration (P < 0. 001). They had more ST-Elevation Myocardial Infarction (STEMI) and evolved with higher Killip classes (P < 0. 001). Increased NT-proBNP levels were also associated with higher peak values of Creatinine Kinase (CK) and troponin (r = 0. 36, P < 0. 001 and r = 0. 37, P < 0. 001), higher left ventricular mass (P = 0. 021), larger left atria (P = 0. 013), and higher prevalence of regional LV hypocontractility (P = 0. 012 to P = 0. 090). During the 4. 2 [2. 1-5. 4] years of follow-up, the composite outcome occurred in 19 patients. After adjusting for age, sex, and Killip class, NT-proBNP was not associated with the composite outcome (HR = 1. 18; 95% CI: 0. 78-1. 78). Conclusion: Post-ACS patients with preserved LVEF and increased levels of NT-proBNP were older, had more comorbidities, and presented with a more severe myocardial infarction. However, NT-proBNP levels measured during ACS hospitalization did not predict the clinical adverse outcomes.

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APA: Copy

Fontes Oliveira, Marta, Martins, Filipe, GOMES, LUISA, Trepa, Maria, Baggen Santos, Raquel, Costa, Ricardo, Rodrigues, Patricia, Luz, Andre, Cabral, Sofia, & Torres, Severo. (2019). Correlates and Prognostic Value of NT-proBNP in Post-Acute Coronary Syndrome Patients with Preserved Left Ventricular Ejection Fraction. INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL, 13(4), 127-132. SID. https://sid.ir/paper/767074/en

Vancouver: Copy

Fontes Oliveira Marta, Martins Filipe, GOMES LUISA, Trepa Maria, Baggen Santos Raquel, Costa Ricardo, Rodrigues Patricia, Luz Andre, Cabral Sofia, Torres Severo. Correlates and Prognostic Value of NT-proBNP in Post-Acute Coronary Syndrome Patients with Preserved Left Ventricular Ejection Fraction. INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL[Internet]. 2019;13(4):127-132. Available from: https://sid.ir/paper/767074/en

IEEE: Copy

Marta Fontes Oliveira, Filipe Martins, LUISA GOMES, Maria Trepa, Raquel Baggen Santos, Ricardo Costa, Patricia Rodrigues, Andre Luz, Sofia Cabral, and Severo Torres, “Correlates and Prognostic Value of NT-proBNP in Post-Acute Coronary Syndrome Patients with Preserved Left Ventricular Ejection Fraction,” INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL, vol. 13, no. 4, pp. 127–132, 2019, [Online]. Available: https://sid.ir/paper/767074/en

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