EAVALUATION OF ANTINOCICEPTIC EFFECT OF NANO-EMULSION GEL CONATAINING ROSEMARY AND PEPPERMINT ESSENTIAL OILS IN A RAT MODEL OF OSTEOARTHRITIS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Mohammadifar Mojgan; TALAEI SAYYED ALIREZA; VAKILI ZARICHEHR; BAHMANI FERESHTEH; Memarzadeh Mohammad Reza; AARABI MOHAMMAD HOSSEIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:23 | Issue:4 (96) Page(s): 100-109

Download Full-Text

Persian Verion

View:

580

Download:

Cites:

Information Journal Paper

Title

EAVALUATION OF ANTINOCICEPTIC EFFECT OF NANO-EMULSION GEL CONATAINING ROSEMARY AND PEPPERMINT ESSENTIAL OILS IN A RAT MODEL OF OSTEOARTHRITIS

Author(s)

Keywords

NANO-EMULSIONQ1

ESSENTIAL OILQ2

ROSMARINUS OFFICINALIS L.Q2

MENTHA PIPERITAQ2

OSTEOARTHRITISQ2

PAINQ2

RATQ1

Abstract

Background and Aim: Despite identification of the antinociceptive effects of rosemary and peppermint ESSENTIAL OILs, use of these ESSENTIAL OILs has been limited due to its low solubility in water and low bioavailability. Use of nanoparticles is one of the ways to overcome these limitations. The aim of this study was to evaluate the antinociceptive effect of NANO-EMULSIONs containing rosemary and peppermint ESSENTIAL OILs in an animal model of OSTEOARTHRITIS (OA).Materials and Methods: In this experimental study NANO-EMULSIONs containing rosemary and peppermint ESSENTIAL OILs were prepared by spontaneous emulsification. In order to investigate the analgesic effect, 30 male RATs were randomly assigned to 5 groups: sham (receiving saline injection into the knee), OSTEOARTHRITIS (receiving intra-articular injection of 2 mg monosodiumiodoacetate), OA (receiving gels containing NANO-EMULSION, or rosemary and peppermint ESSENTIAL OIL or diclofenac sodium). Treatments were administered topically at a dose of 1 ml daily. Mechanical and thermal allodynia and thermal hyperalgesia tests were performed on the 1st, 4th, 7th and 14th days after injection. Data were analyzed by repeated measures ANOVA.Results: OA group showed a significant increased behavioral response to the mechanical and thermal stimuli on all days of the experiment compared to the control group (P<0.001). Use of NANO-EMULSION or diclofenac gel led to significant increase in the response threshold to von- Frey fillamets (P<0.001), decreased response to acetone (P<0.05), and increased paw withdrawal latency (P<0.05). Histopathology of knee tissues confirmed the results of behavioral tests.Conclusion: NANO-EMULSION containing ESSENTIAL OILs of rosemary and peppermint reduced PAIN of OSTEOARTHRITIS in RATs. The nano-emulsification process seems to enhance the antinociceptive effect of rosemary and peppermint ESSENTIAL OILs.

Cites

No record.

References

No record.

Cite

APA: Copy

Mohammadifar, Mojgan, TALAEI, SAYYED ALIREZA, VAKILI, ZARICHEHR, BAHMANI, FERESHTEH, Memarzadeh, Mohammad Reza, & AARABI, MOHAMMAD HOSSEIN. (2018). EAVALUATION OF ANTINOCICEPTIC EFFECT OF NANO-EMULSION GEL CONATAINING ROSEMARY AND PEPPERMINT ESSENTIAL OILS IN A RAT MODEL OF OSTEOARTHRITIS. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 23(4 (96) ), 100-109. SID. https://sid.ir/paper/76750/en

Vancouver: Copy

Mohammadifar Mojgan, TALAEI SAYYED ALIREZA, VAKILI ZARICHEHR, BAHMANI FERESHTEH, Memarzadeh Mohammad Reza, AARABI MOHAMMAD HOSSEIN. EAVALUATION OF ANTINOCICEPTIC EFFECT OF NANO-EMULSION GEL CONATAINING ROSEMARY AND PEPPERMINT ESSENTIAL OILS IN A RAT MODEL OF OSTEOARTHRITIS. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;23(4 (96) ):100-109. Available from: https://sid.ir/paper/76750/en

IEEE: Copy

Mojgan Mohammadifar, SAYYED ALIREZA TALAEI, ZARICHEHR VAKILI, FERESHTEH BAHMANI, Mohammad Reza Memarzadeh, and MOHAMMAD HOSSEIN AARABI, “EAVALUATION OF ANTINOCICEPTIC EFFECT OF NANO-EMULSION GEL CONATAINING ROSEMARY AND PEPPERMINT ESSENTIAL OILS IN A RAT MODEL OF OSTEOARTHRITIS,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 4 (96) , pp. 100–109, 2018, [Online]. Available: https://sid.ir/paper/76750/en

Related Journal Papers