A Survey on the Role of Interleukin-10 in Breast Cancer: A Narrative

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Sheikhpour Elnaz; Noorbakhsh Parisa; Foroughi Elnaz; Farahnak Soudabeh; NASIRI REZVAN; NEAMATZADEH HOSSEIN

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Journal: REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY Year:2018 | Volume:7 | Issue:1 Page(s): 30-37

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Title

A Survey on the Role of Interleukin-10 in Breast Cancer: A Narrative

Author(s)

Keywords

Breast cancer

Cytokine

IL-10

Abstract

Interleukin (IL)-10, a multifunctional immune-regulatory Cytokine with both immunosuppressive and antiangiogenic functions, is produced by immune cells including macrophages, T lymphocytes, and natural killer cells. Among other effects, IL-10 promotes tumor cell proliferation and metastasis via immunosuppression. Interleukin-10-mediated immunosuppression is aided by synthesis of tumor necrosis factor, IL-1, IL-12, and chemokines, and down regulation of the surface co-stimulatory molecules CD80 and CD86 on tumors. Interleukin-10 also promotes IL-6 expression and synthesis, which causes cell proliferation via B cell lymphoma-2 (Bcl-2) upregulation and changes the proliferation/apoptosis equivalence toward neoplastic cell proliferation. Moreover, IL-10 inhibits tumorigenesis via down-regulation of VEGF, IL-1b, TNF-α , IL-6, and MMP-9. Interleukin-10 also inhibits nuclear factor-κ B (NF-κ B) translocation. Interleukin-10 has been reported to have both tumor-promoting and-inhibiting properties. It seems that IL-10 agonists and antagonists may have therapeutic effects via different mechanisms. Moreover, IL-10 gene polymorphisms may determine Breast cancer susceptibility.

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APA: Copy

Sheikhpour, Elnaz, Noorbakhsh, Parisa, Foroughi, Elnaz, Farahnak, Soudabeh, NASIRI, REZVAN, & NEAMATZADEH, HOSSEIN. (2018). A Survey on the Role of Interleukin-10 in Breast Cancer: A Narrative. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 7(1), 30-37. SID. https://sid.ir/paper/767591/en

Vancouver: Copy

Sheikhpour Elnaz, Noorbakhsh Parisa, Foroughi Elnaz, Farahnak Soudabeh, NASIRI REZVAN, NEAMATZADEH HOSSEIN. A Survey on the Role of Interleukin-10 in Breast Cancer: A Narrative. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY[Internet]. 2018;7(1):30-37. Available from: https://sid.ir/paper/767591/en

IEEE: Copy

Elnaz Sheikhpour, Parisa Noorbakhsh, Elnaz Foroughi, Soudabeh Farahnak, REZVAN NASIRI, and HOSSEIN NEAMATZADEH, “A Survey on the Role of Interleukin-10 in Breast Cancer: A Narrative,” REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 7, no. 1, pp. 30–37, 2018, [Online]. Available: https://sid.ir/paper/767591/en

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