ASSESSMENT OF EFFICACY OF SIMVASTATIN ON ISCHEMIC INJURY OF BRAIN IN AN EMBOLIC MODEL OF STROKE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHAABANZADEH A.R.; VANG CH.; SHOUEIB A.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

978

Download:

Cites:

Information Journal Paper

Title

ASSESSMENT OF EFFICACY OF SIMVASTATIN ON ISCHEMIC INJURY OF BRAIN IN AN EMBOLIC MODEL OF STROKE

Author(s)

SHAABANZADEH A.R. | VANG CH. | SHOUEIB A. | Issue Writer Certificate

Keywords

STROKEQ2

SIMVASTATINQ2

HYPERTHERMIAQ4

TISSUE PLASMINOGEN ACTIVATORQ2

Abstract

Background and Aim: Statins have been used in neuroprotection after cerebral ischemia. However, their mechanisms of action remain unknown. We have previously shown the protective effect of statins after cerebral ischemic injury. We have also shown that HYPERTHERMIA can exacerbate cerebral ischemic injury and that the efficacy of TISSUE PLASMINOGEN ACTIVATOR (tPA) is reduced in the presence of HYPERTHERMIA. In this study the effect of SIMVASTATIN alone or in combination with HYPERTHERMIA on brain ischemic injury was evaluated. Materials and Methods: This was an experimental study. Sample size comprised 13 groups of male rats. In four studies, the rectal and brain temperature of the rats were measured and neuroprotective effect of SIMVASTATIN alone or in combination with HYPERTHERMIA in thromboebolic STROKE was evaluated. The collected data were analyzed by means of sigmastat 3.1 soft ware and statistical tests of ANOVA, Tukey and Krascal walis. Resul1s: The results of this study showed that brain temperature was approximately O.50Clower than that of rectum. Results indicate that SIMVASTATIN alone reduced the infarct volume by 46% compared to the control group (p<0.01). SIMVASTATIN improved neurological deficits and reduced brain edema significantly, (p<0.05). Administration of SIMVASTATIN significantly decreased perfusion deficits and BBB permeability.Conclusion: These studies suggest that SIMVASTATIN is protective in an embolic model of STROKE and can decrease BBB permeability and perfusion deficits in brain injured rats.MCA: middle cerebral artery, BBB: blood- brain barrier, tPA: TISSUE PLASMINOGEN ACTIVATOR.

Cites

No record.

References

No record.

Cite

APA: Copy

SHAABANZADEH, A.R., VANG, CH., & SHOUEIB, A.. (2007). ASSESSMENT OF EFFICACY OF SIMVASTATIN ON ISCHEMIC INJURY OF BRAIN IN AN EMBOLIC MODEL OF STROKE. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 11(4 (SERIAL NUMBER 42)), 6-17. SID. https://sid.ir/paper/76765/en

Vancouver: Copy

SHAABANZADEH A.R., VANG CH., SHOUEIB A.. ASSESSMENT OF EFFICACY OF SIMVASTATIN ON ISCHEMIC INJURY OF BRAIN IN AN EMBOLIC MODEL OF STROKE. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2007;11(4 (SERIAL NUMBER 42)):6-17. Available from: https://sid.ir/paper/76765/en

IEEE: Copy

A.R. SHAABANZADEH, CH. VANG, and A. SHOUEIB, “ASSESSMENT OF EFFICACY OF SIMVASTATIN ON ISCHEMIC INJURY OF BRAIN IN AN EMBOLIC MODEL OF STROKE,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 11, no. 4 (SERIAL NUMBER 42), pp. 6–17, 2007, [Online]. Available: https://sid.ir/paper/76765/en

Related Journal Papers