Evaluation of L-arginine Effects on Refractory Seizures in Epileptic Patients

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Ebrahimi Meimand Hossein Ali; Iran Manesh Farhad; Ansar Mahdi; Molla Mohammadi Hasibeh; EBRAHIMI SEPIDEH

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Journal Paper

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Journal: Journal of Kerman University of Medical Sciences Year:2020 | Volume:27 | Issue:3 Page(s): 213-221

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Title

Evaluation of L-arginine Effects on Refractory Seizures in Epileptic Patients

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Keywords

L arginine

Refractory epilepsy

Epilepsy

Ketogenic diets

Abstract

Background: Epilepsy is one of the common neurological disorders and approximately 0. 5-1% of populations suffers from it. Unfortunately, despite of treatment by antiepileptic drugs, between 20-30% of patients cannot be controlled completely. There are a lot of supplementary therapies for this group of patients and in this study, L-arginine was used as an additional therapy in refractory epileptic patients. Methods: Two groups of epileptic patients (n=21) were selected randomly. Group 1 received lactose as a placebo, and group 2 received L-arginine (twofold of daily need) as a drug for three months. We used a standard questionnaire for evaluating the effect of L-arginine on the quality of life before and after the study. Results: we did not find significant change in the quality of life of patients after using L-arginine, but the epileptic attacks decreased in L-arginine group significantly. Conclusion: L-arginine therapy is safe and can decrease the rate of seizure attacks in refractory epileptic patients, and can be an alternative of Ketogenic diets.

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APA: Copy

Ebrahimi Meimand, Hossein Ali, Iran Manesh, Farhad, Ansar, Mahdi, Molla Mohammadi, Hasibeh, & EBRAHIMI, SEPIDEH. (2020). Evaluation of L-arginine Effects on Refractory Seizures in Epileptic Patients. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 27(3), 213-221. SID. https://sid.ir/paper/767715/en

Vancouver: Copy

Ebrahimi Meimand Hossein Ali, Iran Manesh Farhad, Ansar Mahdi, Molla Mohammadi Hasibeh, EBRAHIMI SEPIDEH. Evaluation of L-arginine Effects on Refractory Seizures in Epileptic Patients. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;27(3):213-221. Available from: https://sid.ir/paper/767715/en

IEEE: Copy

Hossein Ali Ebrahimi Meimand, Farhad Iran Manesh, Mahdi Ansar, Hasibeh Molla Mohammadi, and SEPIDEH EBRAHIMI, “Evaluation of L-arginine Effects on Refractory Seizures in Epileptic Patients,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 3, pp. 213–221, 2020, [Online]. Available: https://sid.ir/paper/767715/en

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