EVALUATION OF ANTILEISHMANIAL EFFECT OF THE PLANT EXTRACT OF ALPHA-PINENE (PISTACIA ATLANTICA) IN VITRO AND IN VIVO

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GHADERI ADEL; KHADEM ERFAN MOHAMMAD BAGHER; BARATI MOHAMMAD; GHADERI SHAHLA

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Journal: Scientific Journal of Kurdistan University of Medical Sciences Year:2018 | Volume:23 | Issue:5 (97) Page(s): 32-44

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Title

EVALUATION OF ANTILEISHMANIAL EFFECT OF THE PLANT EXTRACT OF ALPHA-PINENE (PISTACIA ATLANTICA) IN VITRO AND IN VIVO

Author(s)

GHADERI ADEL | KHADEM ERFAN MOHAMMAD BAGHER | BARATI MOHAMMAD | GHADERI SHAHLA | Issue Writer Certificate

Keywords

PISTACIA ATLANTICAQ1

LEISHMANIA MAJORQ2

AREA OF LESIONQ1

ALPHA-PINENEQ1

MTTQ2

Abstract

background and Aim: Leishmaniasis is a zoonotic disease which presents with a wide range of clinical features, including cutaneous and visceral forms in Iran. Leishmania (L) major is one of the agents responsible for cutaneous leishmaniasis transmitted by the bite of sand fly. In this study we assessed the antileishmania effect of PISTACIA ATLANTICA (alpha-pinene) in culture and also its therapeutic effects on Balb/c mice infected withL. Major.Material and Method: Certain amount of promastigots was challenged with increasing concentrations of PISTACIA ATLANTICA extract. MTT test was used to assess promastigote survival after 24, 48 and 72 hours. For in vivo assessment, in the stationary phase, 0.1 ml solution containing 2×106 promastigotes were injected subcutaneously into the base of the tails of the mice. Four weeks after injection, cutaneous lesions appeared and different doses of the extract were applied daily in the form of an ointment for 3 weeks. Diameters of the lesions were measured at the end of each week and therapeutic effect of the extract on the lesions was assessed.Results: The results of MTT test revealed remarkable effect of the treatment on the growth of promastigots. IC50 values for glucantime andalpha pinene were found to be 10 mg/ml and 1.46 mg/ml respectively.30 % ointment of the extract decreased the lesion diameter significantly while 15% ointment and treatment for control group were ineffective.Conclusion: The results of the present study showed antileishmanial effect of ALPHA-PINENE on LEISHMANIA MAJOR promastigots, in vitro. Moreover, topical ointment of the extract can reduce size of the lesions caused by the parasite, in vivo.

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APA: Copy

GHADERI, ADEL, KHADEM ERFAN, MOHAMMAD BAGHER, BARATI, MOHAMMAD, & GHADERI, SHAHLA. (2018). EVALUATION OF ANTILEISHMANIAL EFFECT OF THE PLANT EXTRACT OF ALPHA-PINENE (PISTACIA ATLANTICA) IN VITRO AND IN VIVO. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 23(5 (97) ), 32-44. SID. https://sid.ir/paper/76809/en

Vancouver: Copy

GHADERI ADEL, KHADEM ERFAN MOHAMMAD BAGHER, BARATI MOHAMMAD, GHADERI SHAHLA. EVALUATION OF ANTILEISHMANIAL EFFECT OF THE PLANT EXTRACT OF ALPHA-PINENE (PISTACIA ATLANTICA) IN VITRO AND IN VIVO. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;23(5 (97) ):32-44. Available from: https://sid.ir/paper/76809/en

IEEE: Copy

ADEL GHADERI, MOHAMMAD BAGHER KHADEM ERFAN, MOHAMMAD BARATI, and SHAHLA GHADERI, “EVALUATION OF ANTILEISHMANIAL EFFECT OF THE PLANT EXTRACT OF ALPHA-PINENE (PISTACIA ATLANTICA) IN VITRO AND IN VIVO,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 5 (97) , pp. 32–44, 2018, [Online]. Available: https://sid.ir/paper/76809/en

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