EFFECT OF SODIUM VALPROATE ON ADJUSTING INCREASED HIPPOCAMPAL LEVELS OF NF-KB, S100B AND GFAP FOLLOWING ALLOXAN INDUCED DIABETES

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AMIRPOUR NAJAFABADI BEHNAM; GHOLAMI MAHSA; ZARIE PARVIN; HOSSIENI SIRVAN; SADEGH MEHDI

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Journal: SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:23 | Issue:5 (97) Page(s): 78-87

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Title

EFFECT OF SODIUM VALPROATE ON ADJUSTING INCREASED HIPPOCAMPAL LEVELS OF NF-KB, S100B AND GFAP FOLLOWING ALLOXAN INDUCED DIABETES

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Keywords

DIABETIC NEUROPATHYQ2

HYPERGLYCEMIAQ1

VALPROIC ACIDQ2

Abstract

Background and Aim: Peripheral and central nervous system neuropathy occur in chronic diabetes with uncontrolled HYPERGLYCEMIA. Beneficial effects of sodium valproate have been demonstrated in neurodegenerative diseases. Sodium valproate has neuroprotective and regenerative effects via modifications in gene expression. In this study, we investigated effects of sodium valproate on the modifications in the hippocampal levels of NF-KB, AP-1, S100B and GFAP as a consequence of alloxan induced diabetes.Material and Methods: This experimental study included 24 adult male C57B15/J mice. Diabetes was induced by injection of alloxan (150 mg/kg; i.p.). Sodium valproate was administrated (100 mg/kg; i.p) every 72 hours for two months. Fasting blood sugarlevels were measured at the beginning and at the end of the experiment. Then animals were killed, their hippocampuses were extracted and prepared for measurement of biochemical factors by ELISA kits.Results: Increased blood glucose levels due to alloxan induced diabetes were significantly reduced following sodium valproate administration (P<0.05). Also, chronic sodium valproate administration in diabetic animals significantly reduced elevated levels of hippocampal NFKB, S100B and GFAP (P<0.05).Conclusion: It seems that sodium valproate can adjust diabetes induced modifications in the biochemical factors of the hippocampus which are indicators of cell damage, and maybe effective in prevention of DIABETIC NEUROPATHY.

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APA: Copy

AMIRPOUR NAJAFABADI, BEHNAM, GHOLAMI, MAHSA, ZARIE, PARVIN, HOSSIENI, SIRVAN, & SADEGH, MEHDI. (2018). EFFECT OF SODIUM VALPROATE ON ADJUSTING INCREASED HIPPOCAMPAL LEVELS OF NF-KB, S100B AND GFAP FOLLOWING ALLOXAN INDUCED DIABETES. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 23(5 (97) ), 78-87. SID. https://sid.ir/paper/76811/en

Vancouver: Copy

AMIRPOUR NAJAFABADI BEHNAM, GHOLAMI MAHSA, ZARIE PARVIN, HOSSIENI SIRVAN, SADEGH MEHDI. EFFECT OF SODIUM VALPROATE ON ADJUSTING INCREASED HIPPOCAMPAL LEVELS OF NF-KB, S100B AND GFAP FOLLOWING ALLOXAN INDUCED DIABETES. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;23(5 (97) ):78-87. Available from: https://sid.ir/paper/76811/en

IEEE: Copy

BEHNAM AMIRPOUR NAJAFABADI, MAHSA GHOLAMI, PARVIN ZARIE, SIRVAN HOSSIENI, and MEHDI SADEGH, “EFFECT OF SODIUM VALPROATE ON ADJUSTING INCREASED HIPPOCAMPAL LEVELS OF NF-KB, S100B AND GFAP FOLLOWING ALLOXAN INDUCED DIABETES,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 5 (97) , pp. 78–87, 2018, [Online]. Available: https://sid.ir/paper/76811/en

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