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Information Journal Paper

Title

Association of cigarette smoking with neuromyelitis opticaimmunoglobulin G sero-positivity in neuromyelitis optica spectrum disorder

Pages

  93-98

Abstract

 Background: Neuromyelitis Optica spectrum disorder (NMOSD) is a neuroinflammatory demyelinating disease caused by the presence of a highly specific serum autoantibody marker, NMO-immunoglobulin G (NMO-IgG), that reacts against the water channel aquaporin-4 (AQP4). The present study examined the association between NMO-IgG sero-positivity and environmental factors such as Cigarette smoking. Methods: A cross-sectional study was conducted in Sina Hospital, a tertiary referral center in Tehran, Iran. All the patients with a definite diagnosis of NMOSD were involved in this study. The enzyme-linked immunosorbent assay (ELISA) was used to examine the AQP4-IgG status. To assess the association between NMO-IgG sero-positivity and Cigarette smoking, a researcher-made questionnaire covering patients’ lifestyle information on smoking habits was designed and administered using the structured face-to-face interviews with the patients. Results: The positive and negative NMO-IgG results were found in 44 (46. 8%) and 50 (53. 2%) patients, respectively. The increased NMO-IgG sero-positivity odds were observed among the lifetime smokers [odds ratio (OR) = 3. 24, 95% confidence interval (CI): 1. 16-9. 08], current smokers (OR = 6. 08, 95% CI: 1. 26-29. 39), and passive smokers (OR = 2. 22, 95% CI: 1. 10-4. 50). Conclusion: Lifetime and current smoking as well as passive smoking can be regarded as risk factors for NMO-IgG sero-positivity. Smoking with its immunological effects can lead to the production of autoantibodies such as NMO-IgG.

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    APA: Copy

    ESKANDARIEH, SHARAREH, NASER MOGHADASI, ABDORREZA, SAHRAIAN, MOHAMMAD ALI, Azimi, Amir Reza, & Molazadeh, Negar. (2019). Association of cigarette smoking with neuromyelitis opticaimmunoglobulin G sero-positivity in neuromyelitis optica spectrum disorder. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), 18(3), 93-98. SID. https://sid.ir/paper/768223/en

    Vancouver: Copy

    ESKANDARIEH SHARAREH, NASER MOGHADASI ABDORREZA, SAHRAIAN MOHAMMAD ALI, Azimi Amir Reza, Molazadeh Negar. Association of cigarette smoking with neuromyelitis opticaimmunoglobulin G sero-positivity in neuromyelitis optica spectrum disorder. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY)[Internet]. 2019;18(3):93-98. Available from: https://sid.ir/paper/768223/en

    IEEE: Copy

    SHARAREH ESKANDARIEH, ABDORREZA NASER MOGHADASI, MOHAMMAD ALI SAHRAIAN, Amir Reza Azimi, and Negar Molazadeh, “Association of cigarette smoking with neuromyelitis opticaimmunoglobulin G sero-positivity in neuromyelitis optica spectrum disorder,” CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), vol. 18, no. 3, pp. 93–98, 2019, [Online]. Available: https://sid.ir/paper/768223/en

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