GOLD STANDARD IN LABORATORY DIAGNOSIS OF CHLAMYDIAL INFECTIONS

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HAJIA M.

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Journal: SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES Year:2001 | Volume:5 | Issue:2 Page(s): 41-49

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Title

GOLD STANDARD IN LABORATORY DIAGNOSIS OF CHLAMYDIAL INFECTIONS

Author(s)

HAJIA M. | Issue Writer Certificate

Keywords

GOLD STANDARDQ4

CHLAMYDIAQ4

DIAGNOSISQ3

Abstract

Chlamydial infections have never diagnosed easily and reliably. Cell culture, that was developed in 1965 by using Mc Coy cell, was the GOLD STANDARD of DIAGNOSIS for many years. This technic has 100% speciefity. However, it has much lower sensitivity. It is also difficult and require long time to performe. It`s sensitivity is affected by many factors and different values are reported. In the best conditions, the highest sensitivity reported by equipped laboratories has been 75-80 percent. Developing technics of enzyme immunoassay (EIA) and direct fluorescent antibody (DFA) and demonstration of some false negative ruslts of cell culture revealed that cell culture is not the main criteria in DIAGNOSIS of CHLAMYDIAl infections. However, these tests have not high specifity with acceptable sensitivity which are essential for every diagnostic test. In the few previous years, several amplification technics have been developed. Regarding high sensitiviy and specifity of these tests, they can be used for screening of CHLAMYDIAl species particularly CHLAMYDIA trachomatis in genital, ophthalmic and non- invasive urinary infections. In contrast to the old tests, they are economical tests for assaying large number of samples. However, further studies are required to evaluate positive and negative predictive values of these tests in populations with high, intermediate and low prevalence of the infections.

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APA: Copy

HAJIA, M.. (2001). GOLD STANDARD IN LABORATORY DIAGNOSIS OF CHLAMYDIAL INFECTIONS. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 5(2), 41-49. SID. https://sid.ir/paper/76859/en

Vancouver: Copy

HAJIA M.. GOLD STANDARD IN LABORATORY DIAGNOSIS OF CHLAMYDIAL INFECTIONS. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2001;5(2):41-49. Available from: https://sid.ir/paper/76859/en

IEEE: Copy

M. HAJIA, “GOLD STANDARD IN LABORATORY DIAGNOSIS OF CHLAMYDIAL INFECTIONS,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 5, no. 2, pp. 41–49, 2001, [Online]. Available: https://sid.ir/paper/76859/en

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