The Comparative Effect of Combination of Metformin and Megestrol Acetate With Megestrol Acetate Alone on Endometrial Growth Disorders

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SAYYAH MELLI MANIZHEH; Pourazad Sanam; Mostafa Gharebaghi Parvin; OULADSAHEBMADAREK ELAHEH; JAFARI SHOBEIRI MEHRI; Rahmani Vahideh

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Journal: International Journal of Women's Health and Reproduction Sciences Year:2018 | Volume:6 | Issue:2 Page(s): 211-215

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Title

The Comparative Effect of Combination of Metformin and Megestrol Acetate With Megestrol Acetate Alone on Endometrial Growth Disorders

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Keywords

Endometrial hyperplasia

Endometrial proliferative disorders

Metformin

Megestrol acetate

Abstract

Objectives: Endometrial hyperplasia has an affinity for progression toward endometrial carcinoma. This study was conducted to compare the effect of Metformin plus Megestrol acetate with Megestrol acetate alone on endometrial histology in the patients with endometrial proliferative and hyperplastic disorders. Materials and Methods: In a single-blind clinical trial, 96 patients with abnormal uterine bleeding and endometrium with irregular or hyperplastic glands with or without atypical foundations were divided randomly into 2 equal groups. Group1 received Metformin 500 mg twice a day plus Megestrol acetate 40 mg daily for 3 months and group 2 received Megestrol acetate 40 mg/d for 3 months. The treatment response was evaluated using pathologic samples of endometrial biopsies 2 weeks after completing the treatment. Results: In both groups, Endometrial hyperplasia was resolved in most cases. Significant decrease was observed within groups in the endometrial thickness before and after the intervention. Comparison of thickness between 2 groups showed that in the Megestrol acetate group, after intervention, significant decrease in the endometrial thickness was revealed (12. 73 ± 6. 04 mm [group 1], versus 8. 55 ± 3. 43 mm [group 2], P < 0. 001). Lack of response to treatment was seen in 7% of group 1 and 4. 9% of group 2 (P=0. 68). None of the groups showed any complications and there was no hysterectomy. Conclusions: Both treatment modalities were effective in treating proliferative and hyperplastic disorders. However, the response to treatment in the megestrol group was greater than that in the megestrol plus Metformin group.

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APA: Copy

SAYYAH MELLI, MANIZHEH, Pourazad, Sanam, Mostafa Gharebaghi, Parvin, OULADSAHEBMADAREK, ELAHEH, JAFARI SHOBEIRI, MEHRI, & Rahmani, Vahideh. (2018). The Comparative Effect of Combination of Metformin and Megestrol Acetate With Megestrol Acetate Alone on Endometrial Growth Disorders. INTERNATIONAL JOURNAL OF WOMEN’S HEALTH AND REPRODUCTION SCIENCES, 6(2), 211-215. SID. https://sid.ir/paper/768866/en

Vancouver: Copy

SAYYAH MELLI MANIZHEH, Pourazad Sanam, Mostafa Gharebaghi Parvin, OULADSAHEBMADAREK ELAHEH, JAFARI SHOBEIRI MEHRI, Rahmani Vahideh. The Comparative Effect of Combination of Metformin and Megestrol Acetate With Megestrol Acetate Alone on Endometrial Growth Disorders. INTERNATIONAL JOURNAL OF WOMEN’S HEALTH AND REPRODUCTION SCIENCES[Internet]. 2018;6(2):211-215. Available from: https://sid.ir/paper/768866/en

IEEE: Copy

MANIZHEH SAYYAH MELLI, Sanam Pourazad, Parvin Mostafa Gharebaghi, ELAHEH OULADSAHEBMADAREK, MEHRI JAFARI SHOBEIRI, and Vahideh Rahmani, “The Comparative Effect of Combination of Metformin and Megestrol Acetate With Megestrol Acetate Alone on Endometrial Growth Disorders,” INTERNATIONAL JOURNAL OF WOMEN’S HEALTH AND REPRODUCTION SCIENCES, vol. 6, no. 2, pp. 211–215, 2018, [Online]. Available: https://sid.ir/paper/768866/en

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