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Information Journal Paper

Title

Nephroprotective activity of virgin coconut oil on diclofenac-induced oxidative nephrotoxicity is associated with antioxidant and anti-inflammatory effects in rats

Pages

  316-324

Abstract

 Objective: Diclofenac is a non-steroidal anti-inflammatory drug linked with considerable organ toxicity caused via increased generation of reactive oxygen species. We evaluated whether the antioxidant effect of virgin coconut oil (VCO) could prevent diclofenac-induced oxidative nephrotoxicity in rats. Materials and Methods: Randomized rats were pre-supplemented orally with VCO (5 or 10 ml/kg body weight) from day 1 to 24, and injected with normal saline or diclofenac (100 mg/kg) from day 22 to day 24 intraperitoneally. Results: Diclofenac significantly (p<0. 05) increased serum urea and creatinine levels. Renal tumor necrosis factor-α (TNF-α ) and malondialdehyde (MDA) levels markedly (p<0. 05) increased, whereas renal glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) activities considerably (p<0. 05) decreased compared to normal control. Histopathological alterations were caused by diclofenac. However, treatment with oral VCO for 21 days prior to diclofenac administration, attenuated histological renal damage, and restored antioxidant enzyme activities and TNF-α levels in kidney. Conclusion: These findings revealed that VCO has potential benefits to prevent diclofenac-induced nephrotoxic damage.

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    APA: Copy

    Famurewa, Ademola C., Akunna, Gabriel G., Nwafor, Joseph, Chukwu, Onyebuchi C., Ekeleme Egedigwe, Chima A., & Oluniran, Janet N.. (2020). Nephroprotective activity of virgin coconut oil on diclofenac-induced oxidative nephrotoxicity is associated with antioxidant and anti-inflammatory effects in rats. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 10(3), 316-324. SID. https://sid.ir/paper/769197/en

    Vancouver: Copy

    Famurewa Ademola C., Akunna Gabriel G., Nwafor Joseph, Chukwu Onyebuchi C., Ekeleme Egedigwe Chima A., Oluniran Janet N.. Nephroprotective activity of virgin coconut oil on diclofenac-induced oxidative nephrotoxicity is associated with antioxidant and anti-inflammatory effects in rats. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2020;10(3):316-324. Available from: https://sid.ir/paper/769197/en

    IEEE: Copy

    Ademola C. Famurewa, Gabriel G. Akunna, Joseph Nwafor, Onyebuchi C. Chukwu, Chima A. Ekeleme Egedigwe, and Janet N. Oluniran, “Nephroprotective activity of virgin coconut oil on diclofenac-induced oxidative nephrotoxicity is associated with antioxidant and anti-inflammatory effects in rats,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 10, no. 3, pp. 316–324, 2020, [Online]. Available: https://sid.ir/paper/769197/en

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