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Information Journal Paper

Title

Biochemical and Haematological Changes in Wistar Rats After Administration of Nickel-And Copper-Drug Complexes of Isonicotinic Acid Hydrazide

Pages

  64-70

Abstract

 Metal ion complexes of synthetic drugs are gaining global attention because of their effectiveness in the management of various ailments. Copper and Nickel drug complexes of Isonicotinic Acid Hydrazide were synthesized and investigated for their toxicological activities in Wistar rats using biochemical and haematological parameters. Thirty (30) Wistar rats (150. 20 ± 3. 42 g) were used and divided into 6 groups (A-F) each containing 5 rats. Groups A and B rats orally received 5% DMSO and 20 mg/kg body weight of Isonicotinic Acid Hydrazide respectively, while those in groups C and D received 20 and 40 mg/kg body weight of Ni (ISO)Cl2 respectively. Rats in groups E and F received same doses as in C and D but corresponding to Cu (ISO)Cl2. Each group received 0. 5 ml corresponding to the agents administered to them for 21 days. The Toxicity in the animals were monitored using standard methods. The ligand and its complexes dose-independently reduced (P < 0. 05) serum activities of Alkaline Phosphatase (ALP) as well as quantities of total cholesterol and Red Blood Cells (RBC) but did not significantly (P > 0. 05) affect parameters such as tissue ALP activities, direct bilirubin, total bilirubin, Creatinine, urea, high density lipoprotein-cholesterol (HDL-C), low density lipoproteincholesterol (LDL-C), atherogenic index, haematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC). This study has scientifically established the Safety of nickel and copper complexes of isonicotinic acid hydrazide. However, caution must be taken in their consumption since they possess Hypocholesterolemic properties.

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    Cite

    APA: Copy

    Bamigboye, Mercy O., Quadri, Luqman A., Ejidike, Ikechukwu P., & Ahmed, Risikat Nike. (2020). Biochemical and Haematological Changes in Wistar Rats After Administration of Nickel-And Copper-Drug Complexes of Isonicotinic Acid Hydrazide. INTERNATIONAL JOURNAL OF MEDICAL REVIEWS, 7(2), 64-70. SID. https://sid.ir/paper/769511/en

    Vancouver: Copy

    Bamigboye Mercy O., Quadri Luqman A., Ejidike Ikechukwu P., Ahmed Risikat Nike. Biochemical and Haematological Changes in Wistar Rats After Administration of Nickel-And Copper-Drug Complexes of Isonicotinic Acid Hydrazide. INTERNATIONAL JOURNAL OF MEDICAL REVIEWS[Internet]. 2020;7(2):64-70. Available from: https://sid.ir/paper/769511/en

    IEEE: Copy

    Mercy O. Bamigboye, Luqman A. Quadri, Ikechukwu P. Ejidike, and Risikat Nike Ahmed, “Biochemical and Haematological Changes in Wistar Rats After Administration of Nickel-And Copper-Drug Complexes of Isonicotinic Acid Hydrazide,” INTERNATIONAL JOURNAL OF MEDICAL REVIEWS, vol. 7, no. 2, pp. 64–70, 2020, [Online]. Available: https://sid.ir/paper/769511/en

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