The Effect of 12 Weeks Aerobic Training on PDX-1 and GLUT2 Gene Expression in the Pancreatic Tissue of Type 2 Diabetic Rats

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Sokhanvar dastjerdi Shokoufeh; BANAEIFAR ABDOLALI; ARSHADI SAJAD; ZAFARI ARDESHIR

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Journal Paper

Paper Information

Journal: Iranian Journal of Diabetes and Obesity Year:2020 | Volume:12 | Issue:2 Page(s): 98-103

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Information Journal Paper

Title

The Effect of 12 Weeks Aerobic Training on PDX-1 and GLUT2 Gene Expression in the Pancreatic Tissue of Type 2 Diabetic Rats

Author(s)

Sokhanvar dastjerdi Shokoufeh | BANAEIFAR ABDOLALI | ARSHADI SAJAD | ZAFARI ARDESHIR | Issue Writer Certificate

Keywords

Aerobic training

PDX-1

GLUT-2

Type 2 diabetes

Abstract

Objective: The aim of this study was to investigate the effect of 12 weeks Aerobic training on PDX-1 and GLUT2 gene expression in the pancreatic tissue of type 2 diabetic rats. Materials and Methods: 21 wistar male rats were placed in 3 groups (healthy, diabetic, aerobic diabetic). Diabetes was induced by peritoneum injection of nicotine amid. Training program lasted 12 weeks, five sessions per week by gradual increase of speed (18 to 26 meters on minutes) and time (10 to 55 minutes) in the form of running on the treadmill. After 12 week Aerobic training, PDX-1 and GLUT-2 genes were measured. Data was analyzed using ANOVA with 5 % significance level. Results: Aerobic training caused a significant increase in the expression of GLUT2 (P-value: 0. 043) and PDX-1 genes (P-value: 0. 007) in the pancreatic tissue of rats with Type 2 diabetes (p value: 0. 05). Also Aerobic training had a significant effect on serum glucose (P-value: 0. 001) and insulin levels (P-value: 0. 001). Conclusion: It is concluded that Aerobic training has significant effects on diabetic control by increasing the expression of PDX1 and GLUT-2 which lowers serum glucose.

Cites

The Effect of Aerobic Exercise and Capsaicin on the Gene Expression of Pancreaticpdx1 and GLUT2 in Rats Fed High-Fat Diet

References

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APA: Copy

Sokhanvar dastjerdi, Shokoufeh, BANAEIFAR, ABDOLALI, ARSHADI, SAJAD, & ZAFARI, ARDESHIR. (2020). The Effect of 12 Weeks Aerobic Training on PDX-1 and GLUT2 Gene Expression in the Pancreatic Tissue of Type 2 Diabetic Rats. IRANIAN JOURNAL OF DIABETES AND OBESITY, 12(2), 98-103. SID. https://sid.ir/paper/769743/en

Vancouver: Copy

Sokhanvar dastjerdi Shokoufeh, BANAEIFAR ABDOLALI, ARSHADI SAJAD, ZAFARI ARDESHIR. The Effect of 12 Weeks Aerobic Training on PDX-1 and GLUT2 Gene Expression in the Pancreatic Tissue of Type 2 Diabetic Rats. IRANIAN JOURNAL OF DIABETES AND OBESITY[Internet]. 2020;12(2):98-103. Available from: https://sid.ir/paper/769743/en

IEEE: Copy

Shokoufeh Sokhanvar dastjerdi, ABDOLALI BANAEIFAR, SAJAD ARSHADI, and ARDESHIR ZAFARI, “The Effect of 12 Weeks Aerobic Training on PDX-1 and GLUT2 Gene Expression in the Pancreatic Tissue of Type 2 Diabetic Rats,” IRANIAN JOURNAL OF DIABETES AND OBESITY, vol. 12, no. 2, pp. 98–103, 2020, [Online]. Available: https://sid.ir/paper/769743/en

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