BT-474 Breast Cancer Cell Apoptosis Induced by Crocin, a Saffron Carotenoid

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Faridi Nassim; Heidarzadeh Hamid; MOHAGHEGHI MOHAMMAD ALI; Bathaie S.Zahra

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Journal Paper

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Journal: Basic & Clinical Cancer Research Year:2019 | Volume:11 | Issue:1 Page(s): 5-15

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Title

BT-474 Breast Cancer Cell Apoptosis Induced by Crocin, a Saffron Carotenoid

Author(s)

Faridi Nassim | Heidarzadeh Hamid | MOHAGHEGHI MOHAMMAD ALI | Bathaie S.Zahra | Issue Writer Certificate

Keywords

HER2++

MTT Assay

Flow Cytometry

UPR

Caspase-9

Anticancer

Abstract

Background: Saffron carotenoids have been known as powerful phytochemicals in breast cancer treatment. The purpose of this study was to investigate the anti-cancer properties of an important saffron carotenoid, crocin, on BT-474 which is a known HER2++ breast cancer cell line. Methods: The effect of crocin on cell viability was investigated using MTT Assay. Apoptosis induction was studied via Flow Cytometry and Western blotting of Caspase-9 and cleaved Caspase-9. Involvement of unfolded protein response (UPR) was also investigated via RT-PCR study of the XBP1 gene. Results: The results showed that crocin treatment decreases the viability of BT-474 cells and induces early and late apoptosis in these cells. The mechanism of crocin action was through the induction of Caspase-9 expression and cleavage. Furthermore, we found that crocin induced XBP1 gene splicing in these cells. Conclusion: The present study provides important evidence that crocin induces apoptosis in BT-474 cells. In addition, the activation of UPR may play a role in the Anticancer effects of crocin.

Cites

Crocetin and crocin decreased cholesterol and triglyceride content of both breast cancer tumors and cell lines

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APA: Copy

Faridi, Nassim, Heidarzadeh, Hamid, MOHAGHEGHI, MOHAMMAD ALI, & Bathaie, S.Zahra. (2019). BT-474 Breast Cancer Cell Apoptosis Induced by Crocin, a Saffron Carotenoid. BASIC & CLINICAL CANCER RESEARCH, 11(1), 5-15. SID. https://sid.ir/paper/769744/en

Vancouver: Copy

Faridi Nassim, Heidarzadeh Hamid, MOHAGHEGHI MOHAMMAD ALI, Bathaie S.Zahra. BT-474 Breast Cancer Cell Apoptosis Induced by Crocin, a Saffron Carotenoid. BASIC & CLINICAL CANCER RESEARCH[Internet]. 2019;11(1):5-15. Available from: https://sid.ir/paper/769744/en

IEEE: Copy

Nassim Faridi, Hamid Heidarzadeh, MOHAMMAD ALI MOHAGHEGHI, and S.Zahra Bathaie, “BT-474 Breast Cancer Cell Apoptosis Induced by Crocin, a Saffron Carotenoid,” BASIC & CLINICAL CANCER RESEARCH, vol. 11, no. 1, pp. 5–15, 2019, [Online]. Available: https://sid.ir/paper/769744/en

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