Crocetin and crocin decreased cholesterol and triglyceride content of both breast cancer tumors and cell lines

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HASHEMI SEYED ALI; BATHAIE SEYEDEH ZAHRA; MOHAGHEGHI MOHAMMAD ALI

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Journal: Avicenna Journal of Phytomedicine Year:2020 | Volume:10 | Issue:4 Page(s): 384-397

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Title

Crocetin and crocin decreased cholesterol and triglyceride content of both breast cancer tumors and cell lines

Author(s)

HASHEMI SEYED ALI | BATHAIE SEYEDEH ZAHRA | MOHAGHEGHI MOHAMMAD ALI | Issue Writer Certificate

Keywords

Lipid content 4T1

induced breast tumor MDA

231 MCF

7 HMGCR Docking Binding affinity

Abstract

Objective: Inhibition of lipid metabolism in breast cancer has been suggested as an effective approach for cancer therapy. Saffron-derived crocetin (Crt) and crocin (Cro) with the known anticancer activity, have shown hypolipidemic effect in diabetes and atherosclerosis. Here, we investigated the effect of Crt/Cro on lipid content in breast cancer. Materials and Methods: A multi-model approach involving in vivo, in vitro and in silico studies was applied. The 4T1-induced breast cancer in mice was used to investigate the effect of Crt/Cro on cholesterol (Chl) and triglyceride (TG) levels in serum and tumor tissues. The Chl/TG levels were also assessed in the cytosol of MDA-MB-231 and MCF-7 breast cancer cell lines 6, 12 and 24 hr after Crt/Cro treatment. The interaction between Crt/Cro and hydroxymethylglutaryl coenzyme A reductase (HMGCR) was also computed by docking analysis. Results: Crt reduced both serum (p=0. 003) and tumor (p=0. 011) Chl and TG (p=0. 001) levels in mice. Cro reduced TG levels in tumor (p=0. 014) and serum (p=0. 002) and Chl level in tumor (p=0. 013) tissues. Crt reduced both Chl and TG in MDA-MB-231 (p=0. 014 and p=0. 002, respectively) and MCF-7 (p=0. 014 and p=0. 002, respectively), after 24 h. Cro reduced both Chl and TG in MDA-MB-231 (p=0. 014 and p=0. 002, respectively) and MCF-7 (p=0. 014 and p=0. 002, respectively), after 24 h. Crt binds to the active site of HMGCR with higher affinity (Δ G0=-6. 6 kcal/mol) than simvastatin (Δ G0 =-6. 0 kcal/mol). Conclusion: Crt and Cro effectively decreased Chl/TG content in the sera of tumor bearing mice, in breast tumors and breast cancer cell lines. Crt showed a higher hypolipidemic potential than Cro. In silico analysis indicated Crt binding in the HMGCR active site.

Cites

Increased protein expression of ABCA1, HMG-CoA reductase, and CYP46A1 induced by garlic and allicin in the brain mouse and astrocytes-isolated from C57BL/6J

References

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APA: Copy

HASHEMI, SEYED ALI, BATHAIE, SEYEDEH ZAHRA, & MOHAGHEGHI, MOHAMMAD ALI. (2020). Crocetin and crocin decreased cholesterol and triglyceride content of both breast cancer tumors and cell lines. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 10(4), 384-397. SID. https://sid.ir/paper/764888/en

Vancouver: Copy

HASHEMI SEYED ALI, BATHAIE SEYEDEH ZAHRA, MOHAGHEGHI MOHAMMAD ALI. Crocetin and crocin decreased cholesterol and triglyceride content of both breast cancer tumors and cell lines. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2020;10(4):384-397. Available from: https://sid.ir/paper/764888/en

IEEE: Copy

SEYED ALI HASHEMI, SEYEDEH ZAHRA BATHAIE, and MOHAMMAD ALI MOHAGHEGHI, “Crocetin and crocin decreased cholesterol and triglyceride content of both breast cancer tumors and cell lines,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 10, no. 4, pp. 384–397, 2020, [Online]. Available: https://sid.ir/paper/764888/en

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