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Information Journal Paper

Title

Management of Elderly Breast Cancer Patients Referred to the Cancer Institute of Iran during 2000-2014: Call For a National Guideline

Pages

  22-29

Keywords

Disease-free survival (DFS) 

Abstract

 Background: About one-third of total breast cancer cases occur in women over 65 years of age. Elderly breast cancer management is a major oncology challenge across the globe. Unlike radical treatment of younger women’ s mammary tumors, the method used for treatment in Elderly breast cancer depends on patient life expectancy. The present study aims to determine the clinical and pathological characteristics of Elderly breast cancer in Iranian patients and to identify modal treatment differences compared to developed countries. Methods: A total of 239 cases of breast cancer patients over 65 years who had been referred to the Cancer Institute of Iran between 2000 and 2014 were studied and their demographic, pathologic, surgical, and Adjuvant therapy data were recorded. In addition, the two parameters of Recurrence and disease-free survival (DFS) were analyzed statistically. Results: The mean age of patients was 71. 8± 6. 15 and invasive ductal carcinoma (IDC) was the most commonly occurring tumor among these case. In terms of tumor size, 52. 5% of cases were T2, and in terms of axillary lymph node involvement, 53. 2% were N1. Stage II had the highest measured rate and metastasis had occurred in 16% of patients, when analyzed during follow up. 74. 2% of patients were positive for hormone receptors and 33. 1% for HER-2. In terms of treatment, 64. 6% of patients underwent modified radical mastectomy (MRM), 76. 8% chemotherapy, 75. 1% radiotherapy, and 54% hormone therapy. In 54-month follow-ups, local and systemic Recurrence occurred in 27 patients, most of which occurred during the first 4 years; 79 patients died of cancer during the same period. Conclusion: Our results showed that patients’ tumor stage was higher than similar studies, and despite the radical regimen strategies in Iran, the risk of Recurrence and mortality was higher. Therefore, it is suggested that the study be repeated in other major treatment centers in Iran. We suggest that the treatment of Elderly breast cancer be carried out with the help of a multidisciplinary team, and to develop national guidelines for these patients.

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    APA: Copy

    Miratashi yazdi, Seyed Masoud, Najafi, Masoume, Mohammadnejad, Ahad, OMRANIPOUR, RAMESH, & Shirkhoda, Mohammad. (2018). Management of Elderly Breast Cancer Patients Referred to the Cancer Institute of Iran during 2000-2014: Call For a National Guideline. BASIC & CLINICAL CANCER RESEARCH, 10(3), 22-29. SID. https://sid.ir/paper/769853/en

    Vancouver: Copy

    Miratashi yazdi Seyed Masoud, Najafi Masoume, Mohammadnejad Ahad, OMRANIPOUR RAMESH, Shirkhoda Mohammad. Management of Elderly Breast Cancer Patients Referred to the Cancer Institute of Iran during 2000-2014: Call For a National Guideline. BASIC & CLINICAL CANCER RESEARCH[Internet]. 2018;10(3):22-29. Available from: https://sid.ir/paper/769853/en

    IEEE: Copy

    Seyed Masoud Miratashi yazdi, Masoume Najafi, Ahad Mohammadnejad, RAMESH OMRANIPOUR, and Mohammad Shirkhoda, “Management of Elderly Breast Cancer Patients Referred to the Cancer Institute of Iran during 2000-2014: Call For a National Guideline,” BASIC & CLINICAL CANCER RESEARCH, vol. 10, no. 3, pp. 22–29, 2018, [Online]. Available: https://sid.ir/paper/769853/en

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