Clinical and Laboratory Investigation of Children with Systemic Lupus Erythematosus (SLE) Referring to Lupus Clinic of Dr. Sheikh Hospital, Mashhad, Iran

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Chaichi Zahra; ESMAEILI MOHAMMAD; MALEK ABDOLREZA; Ghane Sharbaf Fatemeh; AZARFAR ANOUSH; Ghaffarian Eidgahi Moghaddam Nafiseh; Sarvari Gholamreza; GHAHREMANI SARA

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Journal Paper

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Journal: Journal of Pediatric Perspectives Year:2019 | Volume:7 | Issue:8 (68) Page(s): 9893-9902

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Title

Clinical and Laboratory Investigation of Children with Systemic Lupus Erythematosus (SLE) Referring to Lupus Clinic of Dr. Sheikh Hospital, Mashhad, Iran

Author(s)

Keywords

Children

Clinical symptoms

Laboratory results

Systemic Lupus Erythematous

Abstract

Background: Systemic Lupus Erythematous (SLE) is a multisystemic and autoimmune inflammatory disease characterized by production of autoantibodies against different cellular components. We aimed to investigate Children with SLE in terms of Clinical symptoms and laboratory findings who referred to Lupus clinic. Materials and Methods: In this cross-sectional study, 36 Children with SLE referring to lupus clinic of Dr. Sheikh hospital, Mashhad-Iran, were enrolled for one year. Clinical symptoms and involvement of different organs were completely checked and recorded at the time of diagnosis of lupus disease based on questionnaire information. The patients with nephritic manifestations of lupus underwent needle biopsies of kidneys, with the samples being examined by light microscope and immunofluorescence to investigate the extent of renal involvement. The main course of treatment included steroid-cyclophosphamide (injection and oral), hydroxychloroquine-mycophenolate (Cellcept) and Azathioprine. Then, response or lack of treatment response as well as the extent and severity of relapse were recorded based on questionnaire. Results: In this study, out of 36 lupus patients, 30 were female (83. 3%). The mean age was 9. 15± 4. 28 years. Lupus nephritis, musculoskeletal manifestations, hematological manifestations, cutaneous manifestations, and neurological manifestations existed in 20 (55. 6%), 11 (30. 6%), 9 (25. 0%), 7 (19. 4%), and 4 (11. 1%), respectively. There was no significant relationship between the age plus gender and lupus clinical manifestations. However, there was a significant relationship between relapse of disease and lupus nephritis (p<0. 05). Conclusion: The results of this study indicated that nephrological, musculoskeletal, hematological, and neurological manifestations are among the most common manifestations of childhood onset lupus. Concerning the diversity of symptoms in patients with lupus, performing precise examinations especially renal examinations is recommended.

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References

Pediatric Systemic Lupus Erythematosus: Learning From Longer Follow Up to Adulthood

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APA: Copy

Chaichi, Zahra, ESMAEILI, MOHAMMAD, MALEK, ABDOLREZA, Ghane Sharbaf, Fatemeh, AZARFAR, ANOUSH, Ghaffarian Eidgahi Moghaddam, Nafiseh, Sarvari, Gholamreza, & GHAHREMANI, SARA. (2019). Clinical and Laboratory Investigation of Children with Systemic Lupus Erythematosus (SLE) Referring to Lupus Clinic of Dr. Sheikh Hospital, Mashhad, Iran. INTERNATIONAL JOURNAL OF PEDIATRICS, 7(8 (68)), 9893-9902. SID. https://sid.ir/paper/770864/en

Vancouver: Copy

Chaichi Zahra, ESMAEILI MOHAMMAD, MALEK ABDOLREZA, Ghane Sharbaf Fatemeh, AZARFAR ANOUSH, Ghaffarian Eidgahi Moghaddam Nafiseh, Sarvari Gholamreza, GHAHREMANI SARA. Clinical and Laboratory Investigation of Children with Systemic Lupus Erythematosus (SLE) Referring to Lupus Clinic of Dr. Sheikh Hospital, Mashhad, Iran. INTERNATIONAL JOURNAL OF PEDIATRICS[Internet]. 2019;7(8 (68)):9893-9902. Available from: https://sid.ir/paper/770864/en

IEEE: Copy

Zahra Chaichi, MOHAMMAD ESMAEILI, ABDOLREZA MALEK, Fatemeh Ghane Sharbaf, ANOUSH AZARFAR, Nafiseh Ghaffarian Eidgahi Moghaddam, Gholamreza Sarvari, and SARA GHAHREMANI, “Clinical and Laboratory Investigation of Children with Systemic Lupus Erythematosus (SLE) Referring to Lupus Clinic of Dr. Sheikh Hospital, Mashhad, Iran,” INTERNATIONAL JOURNAL OF PEDIATRICS, vol. 7, no. 8 (68), pp. 9893–9902, 2019, [Online]. Available: https://sid.ir/paper/770864/en

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