Malathion-increased Hepatotoxicity in Diabetic Rats

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Hosseini Seyedeh Azam; Ahmadipour Ahmad; Soltani Motahareh; MEHDIPOUR MOHAMMAD; MANDEGARY ALI; Karami Mohajeri Somayyeh

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Journal: Pharmaceutical and Biomedical Research Year:2020 | Volume:6 | Issue:1 Page(s): 53-60

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Title

Malathion-increased Hepatotoxicity in Diabetic Rats

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Keywords

Organophosphorus

Diabetes

Liver

Oxidative stress

Abstract

Background: Malathion (MT), an Organophosphorus pesticide, induces hepatotoxicity and is associated with hyperglycemia and the development of Diabetes mellitus. Objectives: This study was aimed to evaluate the effects of sub-acute exposure to sub-lethal dose of MT in the Liver of diabetic rats. Methods: Non-diabetic and streptozotocin-induced diabetic rats received MT at a dose of 150 mg/kg/day orally. After 28 days, fasting blood glucose, Glucose Tolerance Test (GTT), serum aminotransferases, and Liver histopathology and antioxidant status were examined. Results: MT impaired GTT, caused alteration in histopathology of histopathology and antioxidant status of Liver in non-diabetic rats. Impairment in GTT did not observe in diabetic rats exposed to MT, but histopathology changes and antioxidant status alteration was more severe. Conclusion: Repeated sub-lethal dose of MT exacerbated hepatotoxicity in Diabetes condition through further impairment in the antioxidant defense system.

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References

Hydroalcoholic Extract of Iranian Caper Leaves Protects Hepatic Toxicity by Suppressing Oxidative Stress in Mice

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APA: Copy

Hosseini, Seyedeh Azam, Ahmadipour, Ahmad, Soltani, Motahareh, MEHDIPOUR, MOHAMMAD, MANDEGARY, ALI, & Karami Mohajeri, Somayyeh. (2020). Malathion-increased Hepatotoxicity in Diabetic Rats. PHARMACEUTICAL AND BIOMEDICAL RESEARCH, 6(1), 53-60. SID. https://sid.ir/paper/770907/en

Vancouver: Copy

Hosseini Seyedeh Azam, Ahmadipour Ahmad, Soltani Motahareh, MEHDIPOUR MOHAMMAD, MANDEGARY ALI, Karami Mohajeri Somayyeh. Malathion-increased Hepatotoxicity in Diabetic Rats. PHARMACEUTICAL AND BIOMEDICAL RESEARCH[Internet]. 2020;6(1):53-60. Available from: https://sid.ir/paper/770907/en

IEEE: Copy

Seyedeh Azam Hosseini, Ahmad Ahmadipour, Motahareh Soltani, MOHAMMAD MEHDIPOUR, ALI MANDEGARY, and Somayyeh Karami Mohajeri, “Malathion-increased Hepatotoxicity in Diabetic Rats,” PHARMACEUTICAL AND BIOMEDICAL RESEARCH, vol. 6, no. 1, pp. 53–60, 2020, [Online]. Available: https://sid.ir/paper/770907/en

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