Hydroalcoholic Extract of Iranian Caper Leaves Protects Hepatic Toxicity by Suppressing Oxidative Stress in Mice

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KALANTARI HEIBATULLAH; Alijani Anis; Kheradmand Parvin; Goodarzian Maedeh; Zeidooni Leila

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Pharmaceutical and Biomedical Research Year:2019 | Volume:5 | Issue:3 Page(s): 8-14

Download Full-Text

View:

175

Download:

166

Cites:

Information Journal Paper

Title

Hydroalcoholic Extract of Iranian Caper Leaves Protects Hepatic Toxicity by Suppressing Oxidative Stress in Mice

Author(s)

Keywords

Iranian caper

Carbon tetrachloride

Oxidative stress

Liver

Mice

Abstract

Capparis spinosa L. (caper) is an aromatic plant, commonly used in the Mediterranean diet, possessing numerous antioxidant compounds, such as phenols, rutin, tocopherols, carotenoids, and vitamin C in its leaves. Thus, the present study investigated the effects of Iranian caper leaves extract on Oxidative stress caused by CCl4 in the Mice’ s Liver. This study was conducted on 42 male Mice in seven groups. The control group, the sham group, the CCl4 group, the Iranian caper leaves extract 100, 200, and 400 mg/kg + CCl4 groups. Then, Biochemicals, Oxidative stress, and hepatic histopathology parameters were evaluated. The co-administration of Iranian caper leaves extract, and CCl4 significantly decreased the levels of aspartate aminotransferase, alanine aminotransferase, and reactive oxygen species, malondialdehyde (P<0. 001) and significantly increased the levels of glutathione and catalase in comparison with the group treated with CCl4 alone (P<0. 01). Furthermore, Iranian caper leaves extract improved histopathological changes such as the the inflammation and necrosis of hepatocytes. Iranian caper leaves extract has protective effects on hepatotoxicity induced by CCl4, mainly through suppressing Oxidative stress.

Cites

Malathion-increased Hepatotoxicity in Diabetic Rats

References

Cite

APA: Copy

KALANTARI, HEIBATULLAH, Alijani, Anis, Kheradmand, Parvin, Goodarzian, Maedeh, & Zeidooni, Leila. (2019). Hydroalcoholic Extract of Iranian Caper Leaves Protects Hepatic Toxicity by Suppressing Oxidative Stress in Mice. PHARMACEUTICAL AND BIOMEDICAL RESEARCH, 5(3), 8-14. SID. https://sid.ir/paper/770477/en

Vancouver: Copy

KALANTARI HEIBATULLAH, Alijani Anis, Kheradmand Parvin, Goodarzian Maedeh, Zeidooni Leila. Hydroalcoholic Extract of Iranian Caper Leaves Protects Hepatic Toxicity by Suppressing Oxidative Stress in Mice. PHARMACEUTICAL AND BIOMEDICAL RESEARCH[Internet]. 2019;5(3):8-14. Available from: https://sid.ir/paper/770477/en

IEEE: Copy

HEIBATULLAH KALANTARI, Anis Alijani, Parvin Kheradmand, Maedeh Goodarzian, and Leila Zeidooni, “Hydroalcoholic Extract of Iranian Caper Leaves Protects Hepatic Toxicity by Suppressing Oxidative Stress in Mice,” PHARMACEUTICAL AND BIOMEDICAL RESEARCH, vol. 5, no. 3, pp. 8–14, 2019, [Online]. Available: https://sid.ir/paper/770477/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops