Fabrication and Characterisation of Lavender Oil and Plant Phospholipid Based Sumatriptan Succinate Hybrid Nano Lipid Carriers

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Reeta -; Mehmood Rashid; Amaldoss Newton

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Journal: Pharmaceutical and Biomedical Research Year:2020 | Volume:6 | Issue:1 Page(s): 91-104

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Title

Fabrication and Characterisation of Lavender Oil and Plant Phospholipid Based Sumatriptan Succinate Hybrid Nano Lipid Carriers

Author(s)

Reeta - | Mehmood Rashid | Amaldoss Newton | Issue Writer Certificate

Keywords

Lipid nanoparticles

NLC

TEM

Zeta Potential

Migraine

Abstract

Background: Nanostructured Lipid Carriers (NLCs) of Sumatriptan Succinate (SS) were prepared by using lavender oil. In ancient days, lavender oil was used for the treatment of a Migraine. The natural anti-Migraine agent, lavender oil, combined with an anti-Migraine drug such as SS in a nano-formulation, will be a practical alternative approach in Migraine therapy. Objectives: Of sumatriptan succinate were fabricated by using a natural anti-Migraine oil (lavender oil), LECIVA-S70, which is a specialized grade for liposomal dermatological preparation and designed for emulsion, fat infusions, nutraceutical formulations, and parenteral use. It contains 70% phosphatidylcholine, which is not generally present in the regular soy lecithin. Methods: The central composite design technique was used to examine the relationship between independent variables and responses such as lavender oil and LECIVA-S70. The dependent variables were Z-average (R1), Polydispersity Index (PDI) (R2), and % entrapment efficiency (R3). The NLCs were prepared with the double emulsification technique. The Fourier transform infrared spectroscopy, X-ray diffraction, and differential scanning calorimetry analyzed the drug excipient compatibility profile. The developed NLCs were characterized for particle size by using Mastersizer, Zetasizer, and Transmission Electron Microscopy TEM). The membrane diffusion technique studied the in vitro drug release profile. Results: The Mean± SD size of the NLCs ranged from 411. 4± 311. 1 d. nm to 398. 8± 242. 6 d. nm. The best formulation (SNE9) demonstrated an average diameter of 398. 8± 242. 6 d. nm, with the PDI of 0. 216, and Zeta Potential of 17. 18 mV Conclusion: The optimized formula demonstrated the narrow size range, a satisfactory Zeta Potential, high drug loading, and reproducible drug release profile. The NLCs successfully retained the aroma of the lavender oil. According to ANOVA, the PDI (R2) is significant with the central composite design.

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APA: Copy

Reeta, -, Mehmood, Rashid, & Amaldoss, Newton. (2020). Fabrication and Characterisation of Lavender Oil and Plant Phospholipid Based Sumatriptan Succinate Hybrid Nano Lipid Carriers. PHARMACEUTICAL AND BIOMEDICAL RESEARCH, 6(1), 91-104. SID. https://sid.ir/paper/770908/en

Vancouver: Copy

Reeta -, Mehmood Rashid, Amaldoss Newton. Fabrication and Characterisation of Lavender Oil and Plant Phospholipid Based Sumatriptan Succinate Hybrid Nano Lipid Carriers. PHARMACEUTICAL AND BIOMEDICAL RESEARCH[Internet]. 2020;6(1):91-104. Available from: https://sid.ir/paper/770908/en

IEEE: Copy

- Reeta, Rashid Mehmood, and Newton Amaldoss, “Fabrication and Characterisation of Lavender Oil and Plant Phospholipid Based Sumatriptan Succinate Hybrid Nano Lipid Carriers,” PHARMACEUTICAL AND BIOMEDICAL RESEARCH, vol. 6, no. 1, pp. 91–104, 2020, [Online]. Available: https://sid.ir/paper/770908/en

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