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Information Journal Paper

Title

Association of 5-lipoxygenase activating protein gene polymorphism and stroke: A study from north east of Iran

Pages

  114-118

Abstract

 Background: Stroke is a multifactorial disorder and a major cause of morbidity and mortality around the world. There are growing numbers of candidate gene pathways which are thought to be associated with Stroke. Genes involved in lipid metabolism are important issues in Stroke studies. Studying different Polymorphisms in these genes are becoming an interest for researchers. 5-lipoxygenase activating protein (ALOX5AP) is one of these genes. Different studies have provided different relations between ALOX5AP promoter Polymorphism (rs17222919) and Stroke. In the present study, we have evaluated this gene Polymorphism in a population in north east of Iran. Methods: This case-control study took place in Ghaem Hospital, Mashhad, Iran. Patients with computed tomography (CT) or magnetic resonance imaging (MRI) confirmation for ischemic Stroke were enrolled in this study and considered as case group. Healthy persons without ischemic Stroke were control group. During 1-year period of this study, ALOX5AP gene Polymorphism in 200 healthy patients (control group) as well as 228 patients with Stroke (case group) was evaluated by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). Results: All of 428 persons (228 cases and 200 healthy controls) enrolled in this study. The genotype and allele frequency was significantly different between both groups (P = 0. 001 and P = 0. 003, respectively). A total number of 54 patients had G allele in case group in contrast to 27 ones in control group. Also, 174 patients in case group had T allele and 173 persons had this allele in control group. In compression of TT genotype, the risk of developing Stroke in GG and TG genotypes increased by 3. 998 and 1. 643, respectively. Also the risk of ischemic Stroke with G allele would increase by 2. 128. Conclusion: According to our results, ALOX5AP promoter Polymorphism (rs17222919) is related to increased ischemic Stroke in Iranian population.

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    APA: Copy

    ERFANI, MARJAN, SADR NABAVI, ARIANE, JAFARZADEH ESFEHANI, REZA, SHARIATI, MOHAMMAD, Ghanbari Garekani, Leila, Vojdani Chahchaheh, Samaneh, & SASANNEJAD, PAYAM. (2019). Association of 5-lipoxygenase activating protein gene polymorphism and stroke: A study from north east of Iran. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), 18(3), 114-118. SID. https://sid.ir/paper/771014/en

    Vancouver: Copy

    ERFANI MARJAN, SADR NABAVI ARIANE, JAFARZADEH ESFEHANI REZA, SHARIATI MOHAMMAD, Ghanbari Garekani Leila, Vojdani Chahchaheh Samaneh, SASANNEJAD PAYAM. Association of 5-lipoxygenase activating protein gene polymorphism and stroke: A study from north east of Iran. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY)[Internet]. 2019;18(3):114-118. Available from: https://sid.ir/paper/771014/en

    IEEE: Copy

    MARJAN ERFANI, ARIANE SADR NABAVI, REZA JAFARZADEH ESFEHANI, MOHAMMAD SHARIATI, Leila Ghanbari Garekani, Samaneh Vojdani Chahchaheh, and PAYAM SASANNEJAD, “Association of 5-lipoxygenase activating protein gene polymorphism and stroke: A study from north east of Iran,” CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), vol. 18, no. 3, pp. 114–118, 2019, [Online]. Available: https://sid.ir/paper/771014/en

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