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Information Journal Paper

Title

Investigation of Chlamydia pneumoniae Infection in Patients With Multiple Sclerosis: A Case-Control Study

Pages

  36-39

Abstract

 Background: Chlamydia pneumonia has currently been proposed to be involved in Multiple sclerosis (MS) pathogenesis. The aim of this study was to evaluate the serum level of anti-C. pneumoniae immunoglobulin G (IgG) in patients with MS compared to the control group, which may be helpful in further understanding of MS etiology. Methods: The serum was obtained from 66 people with MS and 20 healthy people as patient and control groups, respectively. Serums were matched to the patient’ s age, gender, and place of residence. Finally, anti-C. pneumoniae IgG was measured by a sandwich enzyme-linked immunosorbent assay (ELISA). Results: Sixty-six patients (25 men and 41 women within the age range of 17-56 years and mean ± SD of 35. 53 ± 9. 56) with MS and 20 control subjects (8 men and 12 women with the age range of 25-56 and mean ± SD of 38. 3 ± 9. 66) were enrolled in this study. The mean serum anti-C. pneumoniae IgG of patients with MS (28. 82 ± 33. 54 RU/mL) was compared with that of the control group (4. 075 ± 6. 691 RU/mL) and a statistically significant difference was observed in this regard (P < 0. 001). Conclusions: In general, there was a significant relationship between the incidence of MS and the C. pneumoniae infection. However, the actual involvement of C. pneumoniae in MS is still a matter of debate and needs to be clarified in further studies (e. g., by creating animal models and conducting trial tests).

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    APA: Copy

    KAZEMI, SIMA, LASHTOO AGHAEE, BAHAREH, SOLTANIAN, ALI REZA, MAZDEH, MEHRDOKHT, TAHERI, MOHAMMAD, & ALIKHANI, MOHAMMAD YOUSEF. (2020). Investigation of Chlamydia pneumoniae Infection in Patients With Multiple Sclerosis: A Case-Control Study. AVICENNA JOURNAL OF CLINICAL MICROBIOLOGY AND INFECTION, 7(2), 36-39. SID. https://sid.ir/paper/771517/en

    Vancouver: Copy

    KAZEMI SIMA, LASHTOO AGHAEE BAHAREH, SOLTANIAN ALI REZA, MAZDEH MEHRDOKHT, TAHERI MOHAMMAD, ALIKHANI MOHAMMAD YOUSEF. Investigation of Chlamydia pneumoniae Infection in Patients With Multiple Sclerosis: A Case-Control Study. AVICENNA JOURNAL OF CLINICAL MICROBIOLOGY AND INFECTION[Internet]. 2020;7(2):36-39. Available from: https://sid.ir/paper/771517/en

    IEEE: Copy

    SIMA KAZEMI, BAHAREH LASHTOO AGHAEE, ALI REZA SOLTANIAN, MEHRDOKHT MAZDEH, MOHAMMAD TAHERI, and MOHAMMAD YOUSEF ALIKHANI, “Investigation of Chlamydia pneumoniae Infection in Patients With Multiple Sclerosis: A Case-Control Study,” AVICENNA JOURNAL OF CLINICAL MICROBIOLOGY AND INFECTION, vol. 7, no. 2, pp. 36–39, 2020, [Online]. Available: https://sid.ir/paper/771517/en

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