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Information Journal Paper

Title

Oxidized cholesterol exacerbates toll-like receptor 4 expression and activity in the hearts of rats with myocardial infarction

Pages

  43-50

Abstract

 Introduction: The present study examined the effects of high cholesterol and high oxidized-cholesterol diets on the myocardial expression of TLR4 and pro-inflammatory Cytokine in Rats. Methods: Male Wistar Rats were allocated into 6 groups and fed with a normal diet, cholesterol, and oxidized-cholesterol rich diets with or without isoproterenol-induced Myocardial Infarction. TLR4 and MyD 88 expression and levels tumor necrosis factor alpha (TNF-α ) and interleukin 6 (IL-6) were measured in the heart and serum. Results: Oxidized Cholesterol-fed animals had higher serum levels of oxidized low-density lipoprotein (LDL) (263 ± 13 ng/dL) than the cholesterol-fed animals (98 ± 8 ng/dL; P < 0. 001). A high level of oxidized-LDL caused fibrotic cell formation and enhanced neutrophil infiltration in the absence of MI. Both cholesterol and oxidized-cholesterol upregulated TLR4 mRNA expression and increased TNF-α and IL-6 production in the hearts of Rats with MI. In Rats fed with oxidized-cholesterol the serum and myocardial levels of TNF-α (653 ± 42 pg/mL, 1375 ± 121 pg/100 mg, respectively) were higher than MI group (358± 24 pg/mL, P < 0. 001 and 885 ± 56 pg/100 mg, P < 0. 01). A significant correlation was seen between TLR4 expression and infarct size. Conclusion: These findings suggest that cardiac TLR4 is preferentially upregulated by Oxidized Cholesterol in Rats. Oxidized Cholesterol may have a critical role in cardiac toxicity in the absence of pathological conditions.

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    APA: Copy

    KHORRAMI, ARASH, ZIAEE, MOJTABA, RAMESHRAD, MARYAM, NAKHLBAND, AILAR, MALEKI DIZAJI, NASRIN, & GARJANI, ALIREZA. (2020). Oxidized cholesterol exacerbates toll-like receptor 4 expression and activity in the hearts of rats with myocardial infarction. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, 12(1), 43-50. SID. https://sid.ir/paper/771931/en

    Vancouver: Copy

    KHORRAMI ARASH, ZIAEE MOJTABA, RAMESHRAD MARYAM, NAKHLBAND AILAR, MALEKI DIZAJI NASRIN, GARJANI ALIREZA. Oxidized cholesterol exacerbates toll-like receptor 4 expression and activity in the hearts of rats with myocardial infarction. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH[Internet]. 2020;12(1):43-50. Available from: https://sid.ir/paper/771931/en

    IEEE: Copy

    ARASH KHORRAMI, MOJTABA ZIAEE, MARYAM RAMESHRAD, AILAR NAKHLBAND, NASRIN MALEKI DIZAJI, and ALIREZA GARJANI, “Oxidized cholesterol exacerbates toll-like receptor 4 expression and activity in the hearts of rats with myocardial infarction,” JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, vol. 12, no. 1, pp. 43–50, 2020, [Online]. Available: https://sid.ir/paper/771931/en

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