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Information Journal Paper

Title

The combined effects of cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism and canola, sesame and sesame-canola oils consumption on metabolic response in patients with diabetes and healthy peop

Pages

  185-194

Abstract

 Introduction: Cholesteryl ester transfer protein (CETP) is a key regulating enzyme in the lipid metabolism pathway, and its gene Polymorphism may be a candidate for modulating the metabolic responses to dietary intervention. We thus examined whether the effects of the CETP TaqIB Polymorphism on metabolic profiles were modified by dietary plant oils. Methods: This is a retrospective analysis of data collected during a randomized triple-blind crossover trial. A total of 95 patients with type 2 diabetes and 73 non-diabetes individuals completed a 9-week of the intake of sesame, canola and sesame-Canola Oils. Blood samples were collected at the beginning and at the end of each intervention period for biochemical analysis. Genotyping was done using the polymerase chain reaction-restriction fragment length Polymorphism (PCR-RFLP) method. Results: In diabetes patients, B1B1 homozygotes of the CETP TaqIB Polymorphism compared with B2 carriers (B1B2 + B2B2) had significantly lower diastolic blood pressure, apoB and apoB: apoA-1, and higher Lp(a) after the intake of sesame-Canola Oil, as well as lower insulin and HOMA-IR after the intake of Sesame Oil. There was also a significant effect of genotype on adjusted changes of apoB, apoB: apoA-1, insulin, HOMA-IR and QUICKI. A significant genotype-dietary oils combined effects were observed for diastolic blood pressure, and LDL: HDL, TC: HDL and TG: HDL ratios in diabetes patients. No independent or combined effects of dietary oils and genotypes on outcomes were found in healthy people. Conclusion: There was a modulatory effect of the CETP TaqIB Polymorphism on some metabolic traits in response to plant oils in patients with diabetes. Taken together, the intake of sesame-canola and Canola Oils showed more favorable effects in diabetes patients with B1B1 genotype. Future investigations are needed to confirm these results.

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    APA: Copy

    RAMEZANI JOLFAIE, NAHID, Aghaei, Shiva, FARASHAHI YAZD, EHSAN, MORADI, ALI, MOZAFFARI KHOSRAVI, HASSAN, AMIRI, MOJGAN, Raeisi Dehkordi, Hamidreza, Moghtaderi, Fatemeh, Zimorovat, Alireza, YASINI ARDAKANI, SEYED ALI, & SALEHI ABARGOUEI, AMIN. (2020). The combined effects of cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism and canola, sesame and sesame-canola oils consumption on metabolic response in patients with diabetes and healthy peop. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, 12(3), 185-194. SID. https://sid.ir/paper/772199/en

    Vancouver: Copy

    RAMEZANI JOLFAIE NAHID, Aghaei Shiva, FARASHAHI YAZD EHSAN, MORADI ALI, MOZAFFARI KHOSRAVI HASSAN, AMIRI MOJGAN, Raeisi Dehkordi Hamidreza, Moghtaderi Fatemeh, Zimorovat Alireza, YASINI ARDAKANI SEYED ALI, SALEHI ABARGOUEI AMIN. The combined effects of cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism and canola, sesame and sesame-canola oils consumption on metabolic response in patients with diabetes and healthy peop. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH[Internet]. 2020;12(3):185-194. Available from: https://sid.ir/paper/772199/en

    IEEE: Copy

    NAHID RAMEZANI JOLFAIE, Shiva Aghaei, EHSAN FARASHAHI YAZD, ALI MORADI, HASSAN MOZAFFARI KHOSRAVI, MOJGAN AMIRI, Hamidreza Raeisi Dehkordi, Fatemeh Moghtaderi, Alireza Zimorovat, SEYED ALI YASINI ARDAKANI, and AMIN SALEHI ABARGOUEI, “The combined effects of cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism and canola, sesame and sesame-canola oils consumption on metabolic response in patients with diabetes and healthy peop,” JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, vol. 12, no. 3, pp. 185–194, 2020, [Online]. Available: https://sid.ir/paper/772199/en

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