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Information Journal Paper

Title

Relationship of hypomethylation CpG islands in interleukin-6 gene promoter with IL-6 mRNA levels in patients with coronary atherosclerosis

Pages

  221-228

Abstract

 Introduction: Atherosclerosis is the important cause of most cardiovascular diseases, with high prevalence and mortality. Atherosclerosis is not only a lipid metabolism disorder but also recently is defined as a chronic inflammatory disease. Several studies showed that Interleukin-6 (IL-6) is involved in the pathogenesis of Atherosclerosis. The aim of the present study is the examination of IL6 mRNA Levels and hypomethylation of IL6 promoter in Atherosclerosis patients. Methods: In this assay, a total of 35 cases with Atherosclerosis and 30 controls were enrolled. RNA and DNA were isolated from the peripheral blood of all samples. Mean IL6 Gene Expression was determined by RT-PCR and methylation status at six CpG motifs in IL6 promoter was determined using bisulfite genomic sequencing. Results: Real Time-PCR analysis results showed the mean IL6 RNA level in Atherosclerosis patients candidate for CABG (coronary artery bypass grafting) was significantly higher than controls (P value = 0. 01). Also, the upstream CpG motifs (-1038 to-952) in IL6 promoter were predominantly unmethylated in patients than in the controls (P value = 0. 01). Conclusion: These findings suggest that an increase in IL-6 Gene Expression and its DNA hypomethylation promoter are associated with Atherosclerosis patient’ s candidate for CABG surgery.

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    APA: Copy

    Mohammadpanah, Monireh, HEIDARI, MOHAMMAD MEHDI, KHATAMI, MEHRI, & HADADZADEH, MEHDI. (2020). Relationship of hypomethylation CpG islands in interleukin-6 gene promoter with IL-6 mRNA levels in patients with coronary atherosclerosis. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, 12(3), 221-228. SID. https://sid.ir/paper/772217/en

    Vancouver: Copy

    Mohammadpanah Monireh, HEIDARI MOHAMMAD MEHDI, KHATAMI MEHRI, HADADZADEH MEHDI. Relationship of hypomethylation CpG islands in interleukin-6 gene promoter with IL-6 mRNA levels in patients with coronary atherosclerosis. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH[Internet]. 2020;12(3):221-228. Available from: https://sid.ir/paper/772217/en

    IEEE: Copy

    Monireh Mohammadpanah, MOHAMMAD MEHDI HEIDARI, MEHRI KHATAMI, and MEHDI HADADZADEH, “Relationship of hypomethylation CpG islands in interleukin-6 gene promoter with IL-6 mRNA levels in patients with coronary atherosclerosis,” JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, vol. 12, no. 3, pp. 221–228, 2020, [Online]. Available: https://sid.ir/paper/772217/en

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