Effect of Metformin on Premature Luteinization and Pregnancy Outcomes in Intracytoplasmic Sperm Injection-Fresh Embryo Transfer Cycles: A Randomized Double-Blind Controlled Trial

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Hussein Reda S.; Elnashar Ihab; Amin Ahmed F.; ZHAO YULIAN; Abdelmagied Ahmed M.; Abbas Ahmed M.; Abdelaleem Ahmed A.; Farghaly Tarek A.; Abdalmageed Osama S.; Youssef Ahmed A.; Badran Esraa; Abou Taleb Hisham A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: International Journal of Fertility & Sterility Year:2021 | Volume:15 | Issue:2 Page(s): 108-114

Download Full-Text

View:

227

Download:

188

Cites:

Information Journal Paper

Title

Effect of Metformin on Premature Luteinization and Pregnancy Outcomes in Intracytoplasmic Sperm Injection-Fresh Embryo Transfer Cycles: A Randomized Double-Blind Controlled Trial

Author(s)

Keywords

Infertility

Intracytoplasmic Sperm Injection

Metformin

Pregnancy Outcomes

Abstract

Background: Premature luteinization (PL) is not unusual in in vitro fertilization (IVF) and could not be wholly avoided by using either gonadotropin-releasing hormone (GnRH) agonists or GnRH antagonist regimens. The study aims to evaluate Metformin’ s efficacy in preventing PL in fresh GnRH antagonist Intracytoplasmic Sperm Injection (ICSI) cycles with cleavage-stage embryo transfer. Materials and Methods: This randomized, double-blind, placebo-controlled trial was conducted in a tertiary univer-sity IVF center. We recruited infertile women who were scheduled to perform their first or second ICSI trial. Eligible women were recruited and randomized in a 1: 1 ratio into two groups. Metformin was administered in a dose of 1500 mg per day since the start of contraceptive pills in the cycle antecedent to stimulation cycle until the day of ovulation triggering, while women in the placebo group received a placebo for the same regimen and duration. The primary outcome was the incidence of PL, defined as serum progesterone (P) on the triggering day ≥ 1. 5 ng/mL. Secondary outcomes comprised the live birth, ongoing pregnancy, implantation, and good-quality embryos rates. Results: The trial involved 320 eligible participants (n=160 in each group). Both groups had comparable stimulation days, endometrial thickness, peak estradiol levels, number of oocytes retrieved, and number of mature oocytes. Metformin group experienced lower level of serum P (P<0. 001) and incidence of PL (10 vs. 23. 6%, P=0. 001). Moreover, lower progesterone/estradiol (P/E) ratio and progesterone to mature oocyte index (PMOI) (P=0. 002 and P=0. 002, respectively) were demonstrated in women receiving Metformin. Metformin group generated a better rate of goodquality embryos (P=0. 005) and ongoing pregnancy (43. 8 vs. 31. 8%, P=0. 026). A similar trend, though of borderline significance, was observed in the live birth rate in favor of Metformin administration (38. 15 vs. 27. 5%, P=0. 04). Conclusion: Metformin could be used in patients with potential PL to improve fresh cycle outcomes by preventing PL (Registration number: NCT03088631).

Cites

No record.

References

Cite

APA: Copy

Hussein, Reda S., Elnashar, Ihab, Amin, Ahmed F., ZHAO, YULIAN, Abdelmagied, Ahmed M., Abbas, Ahmed M., Abdelaleem, Ahmed A., Farghaly, Tarek A., Abdalmageed, Osama S., Youssef, Ahmed A., Badran, Esraa, & Abou Taleb, Hisham A.. (2021). Effect of Metformin on Premature Luteinization and Pregnancy Outcomes in Intracytoplasmic Sperm Injection-Fresh Embryo Transfer Cycles: A Randomized Double-Blind Controlled Trial. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 15(2), 108-114. SID. https://sid.ir/paper/772992/en

Vancouver: Copy

Hussein Reda S., Elnashar Ihab, Amin Ahmed F., ZHAO YULIAN, Abdelmagied Ahmed M., Abbas Ahmed M., Abdelaleem Ahmed A., Farghaly Tarek A., Abdalmageed Osama S., Youssef Ahmed A., Badran Esraa, Abou Taleb Hisham A.. Effect of Metformin on Premature Luteinization and Pregnancy Outcomes in Intracytoplasmic Sperm Injection-Fresh Embryo Transfer Cycles: A Randomized Double-Blind Controlled Trial. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2021;15(2):108-114. Available from: https://sid.ir/paper/772992/en

IEEE: Copy

Reda S. Hussein, Ihab Elnashar, Ahmed F. Amin, YULIAN ZHAO, Ahmed M. Abdelmagied, Ahmed M. Abbas, Ahmed A. Abdelaleem, Tarek A. Farghaly, Osama S. Abdalmageed, Ahmed A. Youssef, Esraa Badran, and Hisham A. Abou Taleb, “Effect of Metformin on Premature Luteinization and Pregnancy Outcomes in Intracytoplasmic Sperm Injection-Fresh Embryo Transfer Cycles: A Randomized Double-Blind Controlled Trial,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 15, no. 2, pp. 108–114, 2021, [Online]. Available: https://sid.ir/paper/772992/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops