Clinical Experience: Genetic Counseling in the Follow-up of Breast Cancer patients; Conversion of a Luminal Tumor to TNBC

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AHMADI HAMID; HOSSEINPOUR REZA; JAHANBIN BEHNAZ; Majidzadeh A Keivan; AZMOUDEH ARDALAN FARID

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Journal Paper

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Journal: Archives of Breast Cancer Year:2020 | Volume:7 | Issue:1 Page(s): 10-13

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Title

Clinical Experience: Genetic Counseling in the Follow-up of Breast Cancer patients; Conversion of a Luminal Tumor to TNBC

Author(s)

Keywords

Breast Cancer

Genetic counseling

Triple negative

IHC

Conversion

Abstract

Background: Triple-negative subtype does not have any of the receptors that are commonly found in Breast Cancer. Patients suffering from Triple-negative Breast Cancer are at risk of early metastasis and BRCA mutation. The Conversion of the receptors during the metastatic progression or local recurrence of Breast Cancer is a well-known topic that affects the therapeutic measures and outcome. Confirmation of immunohistochemistry is essential in these conditions, but genetic evaluation is controversial. Case presentation: A woman suffering from primary luminal Breast Cancer presented with femoral bone metastasis in the follow-up after two years. Bone metastasis was compatible with the triple-negative subtype. This case was discussed at the weekly breast multidisciplinary team session of the Department of Breast Surgery, Tehran University of Medical Sciences. Question: Does the patient need genetics counseling in a Conversion setting? And does the new specimen need CISH/FISH techniques to confirm TNBC tumors? Conclusion: There are no strong guidelines to recommend Genetic counseling and BRCA testing for patients with Breast Cancer biomarkers Conversion. Re-assessing the specimen for ER, PR, and HER-2 is necessary for this setting.

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APA: Copy

AHMADI, HAMID, HOSSEINPOUR, REZA, JAHANBIN, BEHNAZ, Majidzadeh A, Keivan, & AZMOUDEH ARDALAN, FARID. (2020). Clinical Experience: Genetic Counseling in the Follow-up of Breast Cancer patients; Conversion of a Luminal Tumor to TNBC. ARCHIVES OF BREAST CANCER, 7(1), 10-13. SID. https://sid.ir/paper/774252/en

Vancouver: Copy

AHMADI HAMID, HOSSEINPOUR REZA, JAHANBIN BEHNAZ, Majidzadeh A Keivan, AZMOUDEH ARDALAN FARID. Clinical Experience: Genetic Counseling in the Follow-up of Breast Cancer patients; Conversion of a Luminal Tumor to TNBC. ARCHIVES OF BREAST CANCER[Internet]. 2020;7(1):10-13. Available from: https://sid.ir/paper/774252/en

IEEE: Copy

HAMID AHMADI, REZA HOSSEINPOUR, BEHNAZ JAHANBIN, Keivan Majidzadeh A, and FARID AZMOUDEH ARDALAN, “Clinical Experience: Genetic Counseling in the Follow-up of Breast Cancer patients; Conversion of a Luminal Tumor to TNBC,” ARCHIVES OF BREAST CANCER, vol. 7, no. 1, pp. 10–13, 2020, [Online]. Available: https://sid.ir/paper/774252/en

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