Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

83
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

44
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

The Effect of Detraining High Intensity Interval Training on the Expression of AKT1 and mTORc1 Genes in the Left Ventricle of Diabetic Rats

Author(s)

 Soltanipour jounaghani Farzaneh | PEERI MAGHSOUD | AZARBAYJANI MOHAMMAD ALI | Issue Writer Certificate 

Pages

  37-46

Abstract

 Objective: The aim of this study was to investigate the effect of 6 weeks of Detraining after 12 weeks of High intensity interval training (HIIT) on the expression of AKT1 and mTORc1 genes in the left ventricle of wistar diabetic rats. Materials and Methods: Twenty-eight wistar male rats were selected as the study sample and were divided in four groups of healthy control, diabetic control, diabetic HIIT and diabetic HIIT + Detraining. The HIIT period was 12 weeks and the Detraining period was 6 weeks. Each session consisted of 30 minutes, which included running on a treadmill with one-minute repetitions and a two-minute active recovery between them. To measure AKT1 mRNA and mTORc1 mRNA by RT-Real time PCR, a single-step single step SYBR TAKARA kits from Takara Company was used according to the company's instruction. Results: HIIT caused a significant increase in AKT1 gene expression (P-value= 0. 001). AKT1 decreased with Detraining that was not significant (P-value= 0. 34) but it was still significantly higher than before training (P-value= 0. 017). HIIT caused a significant increase in mTORc1 gene expression (P-value= 0. 001) and although it decreased with Detraining (P-value= 0. 15) and it was no significantly higher than before training (P-value= 0. 19). Conclusion: HIIT led to increased expression of AKT1 and mTORc1 genes in type 2 diabetic rats, while also producing favorable changes in the cardiac structure of these rats. Also, 6 weeks of Detraining did somewhat reduce these favorable changes.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Soltanipour jounaghani, Farzaneh, PEERI, MAGHSOUD, & AZARBAYJANI, MOHAMMAD ALI. (2020). The Effect of Detraining High Intensity Interval Training on the Expression of AKT1 and mTORc1 Genes in the Left Ventricle of Diabetic Rats. IRANIAN JOURNAL OF DIABETES AND OBESITY, 12(1), 37-46. SID. https://sid.ir/paper/774767/en

    Vancouver: Copy

    Soltanipour jounaghani Farzaneh, PEERI MAGHSOUD, AZARBAYJANI MOHAMMAD ALI. The Effect of Detraining High Intensity Interval Training on the Expression of AKT1 and mTORc1 Genes in the Left Ventricle of Diabetic Rats. IRANIAN JOURNAL OF DIABETES AND OBESITY[Internet]. 2020;12(1):37-46. Available from: https://sid.ir/paper/774767/en

    IEEE: Copy

    Farzaneh Soltanipour jounaghani, MAGHSOUD PEERI, and MOHAMMAD ALI AZARBAYJANI, “The Effect of Detraining High Intensity Interval Training on the Expression of AKT1 and mTORc1 Genes in the Left Ventricle of Diabetic Rats,” IRANIAN JOURNAL OF DIABETES AND OBESITY, vol. 12, no. 1, pp. 37–46, 2020, [Online]. Available: https://sid.ir/paper/774767/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top