HISTOMORPHOLOGY OF THE OLFACTORY MUCOSA AND SPINAL TISSUE SPARING FOLLOWING TRANSPLANTATION IN THE PARTIAL SPINAL CORD INJURY IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

DELAVIZ H.; MIRZAEE A.; ROOZBEHI A.; JOGHATAIE M.T.; NAJAFZADEH N.; RAD P.; MOHAMADI J.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Armaghane Danesh Year:2011 | Volume:15 | Issue:4 (60) Page(s): 345-355

Download Full-Text

Persian Verion

View:

715

Download:

Cites:

Information Journal Paper

Title

HISTOMORPHOLOGY OF THE OLFACTORY MUCOSA AND SPINAL TISSUE SPARING FOLLOWING TRANSPLANTATION IN THE PARTIAL SPINAL CORD INJURY IN RATS

Author(s)

Keywords

GLIAQ3

OLFACTORY MUCOSAQ3

SPINAL CORDQ2

TRANSPLANTATIONQ3

Abstract

Introduction & Objective: Nowadays, cellular and tissues transplant has become the focus of attention for SPINAL CORD injury. It has been shown olfactory nerve cells or OLFACTORY MUCOSA whi have more efficient on nervous tissue repair and they have been more studied in experimental study. Furthermore, they were used in a few clinical centers for spinal defect. But mucosa tissue and spinal tissue have different structure and there is doubt about the integration of mucosa tissue in nervous tissue. Thus, in this research the morphology and the effect of the fetal OLFACTORY MUCOSA (FOM) on spinal tissue sparing were studied after transplanted into the SPINAL CORD hemisection in rats.Materials & Methods: This experimental study was conducted at Iran University of Medical Sciences in 2008. Of thirty eight female Sprague-Dawley (200-250g) rats twenty- eight were spinally hemisected at the L1 spinal level and were randomized into two groups of 14 animals. Treatment group received FOM graft and the control group received fetal respiratory mucosa graft (FRM). The other animals received surgical procedure without SPINAL CORD injury as a sham group. The morphology of the transplant region and spinal tissue sparing was examined histological eight weeks after TRANSPLANTATION. The collected data was analyzed by the SPSS software using ANOVA and the morphology of the transplant region were studied by light microscope.Results: Histological study showed that the both mucosa tissues could not integrate with the parenchyma of the spinal tissue. Although the FOM were fused more than the FRM with the host tissue but clear boundary was seen at the graft-host interface. The mean spinal tissue sparing of the treatment group increased a little compare to the control but a significant difference was not apparent whereas, the spinal tissue sparing in treatment and control groups compare to the sham group decreased significantly (P<0.05).Conclusion: TRANSPLANTATION of the mucosa tissue directly, into the SPINAL CORD injury was created different cytoarchitecture with spinal tissue and FOM partially preserving tissue sparing.

Cites

No record.

References

No record.

Cite

APA: Copy

DELAVIZ, H., MIRZAEE, A., ROOZBEHI, A., JOGHATAIE, M.T., NAJAFZADEH, N., RAD, P., & MOHAMADI, J.. (2011). HISTOMORPHOLOGY OF THE OLFACTORY MUCOSA AND SPINAL TISSUE SPARING FOLLOWING TRANSPLANTATION IN THE PARTIAL SPINAL CORD INJURY IN RATS. ARMAGHAN DANESH, 15(4 (60)), 345-355. SID. https://sid.ir/paper/77520/en

Vancouver: Copy

DELAVIZ H., MIRZAEE A., ROOZBEHI A., JOGHATAIE M.T., NAJAFZADEH N., RAD P., MOHAMADI J.. HISTOMORPHOLOGY OF THE OLFACTORY MUCOSA AND SPINAL TISSUE SPARING FOLLOWING TRANSPLANTATION IN THE PARTIAL SPINAL CORD INJURY IN RATS. ARMAGHAN DANESH[Internet]. 2011;15(4 (60)):345-355. Available from: https://sid.ir/paper/77520/en

IEEE: Copy

H. DELAVIZ, A. MIRZAEE, A. ROOZBEHI, M.T. JOGHATAIE, N. NAJAFZADEH, P. RAD, and J. MOHAMADI, “HISTOMORPHOLOGY OF THE OLFACTORY MUCOSA AND SPINAL TISSUE SPARING FOLLOWING TRANSPLANTATION IN THE PARTIAL SPINAL CORD INJURY IN RATS,” ARMAGHAN DANESH, vol. 15, no. 4 (60), pp. 345–355, 2011, [Online]. Available: https://sid.ir/paper/77520/en

Related Journal Papers