Cardioprotective effect of Rosa canina L. methanolic extract on heat shock induced cardiomyocyte injury: An experimental study

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Nasrolahi Ava; HOSSEINI LEILA; Farokhi Sisakht Fatemeh; MAHMOUDI JAVAD; KARIMI POURAN; BADALZADEH REZA; ERFANI MARJAN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Cardiovascular and Thoracic Research Year:2020 | Volume:12 | Issue:4 Page(s): 286-293

Download Full-Text

View:

162

Download:

123

Cites:

Information Journal Paper

Title

Cardioprotective effect of Rosa canina L. methanolic extract on heat shock induced cardiomyocyte injury: An experimental study

Author(s)

Keywords

Rosa canina Oxidative Stress Endoplasmic Reticulum Stress Heat Stress Cell Death

Abstract

Introduction: Overexposure to heat conditions can affect the functioning of the cardiovascular system and may promote cardiovascular disorders. Heat shock induced myocardial injury via increasing endoplasmic reticulum response-mediated apoptosis. This study investigated the impact of pretreatment with Rosa canina (RC), a natural antioxidant, on myocardial damage induced by heat stress exposure and underlying mechanisms in cardiomyocytes in rats. Methods: Sixty adult male Wistar rats were allocated into five groups, including Control: received normal saline (NS), Heat Stress (HS), and HS+RC groups. Animals in the HS groups were subjected to heat stress (43 º C) for 15 minutes once a day for two weeks. Animals in the HS+RC groups received three doses of RC (250, 500, and 1000 mg/mL) one hour before being subjected to heat shock. The endoplasmic reticulum (ER) transmembrane kinases, including PKR-like endoplasmic reticulum kinase (PERK), immunoreactivity of CCAAT/enhancer-binding protein homologous protein (CHOP), and eukaryotic translation initiation factor 2-alpha (eIF2α ) as well as caspase 8 were detected by Western blot. The levels of reactive oxygen species (ROS) were assessed. Moreover, histopathological changes and apoptosis were also assayed in the heart tissue by using histopathological and TUNEL assays. Results: Heat exposure increased the level of ROS and induced oxidative damage in the heart tissue. The results demonstrated that RC administration decreased the overproduction of ROS induced by heat stress in cardiomyocytes. Moreover, heat stress upregulated the expression of p-PERK, p-eIF2α , and CHOP protein while pretreatment with RC decreased expression of ER stress-related markers in cardiomyocytes. Besides, RC diminished heat stress-induced cellular damage and apoptosis associated with inhibition of caspase 8 activation, a pro-apoptotic protein in cardiomyocytes. Conclusion: These findings indicate that RC exerts a protective effect on heart tissue, at least in part, through inactivation of PERK/eIF2α /CHOP pathway or inhibition of ER stress and oxidative stresstriggered apoptosis in cardiomyocytes induced by heat stress.

Cites

No record.

References

Cite

APA: Copy

HOSSEINI, LEILA, Farokhi Sisakht, Fatemeh, MAHMOUDI, JAVAD, KARIMI, POURAN, BADALZADEH, REZA, & ERFANI, MARJAN. (2020). Cardioprotective effect of Rosa canina L. methanolic extract on heat shock induced cardiomyocyte injury: An experimental study. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, 12(4), 286-293. SID. https://sid.ir/paper/775353/en

Vancouver: Copy

HOSSEINI LEILA, Farokhi Sisakht Fatemeh, MAHMOUDI JAVAD, KARIMI POURAN, BADALZADEH REZA, ERFANI MARJAN. Cardioprotective effect of Rosa canina L. methanolic extract on heat shock induced cardiomyocyte injury: An experimental study. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH[Internet]. 2020;12(4):286-293. Available from: https://sid.ir/paper/775353/en

IEEE: Copy

LEILA HOSSEINI, Fatemeh Farokhi Sisakht, JAVAD MAHMOUDI, POURAN KARIMI, REZA BADALZADEH, and MARJAN ERFANI, “Cardioprotective effect of Rosa canina L. methanolic extract on heat shock induced cardiomyocyte injury: An experimental study,” JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, vol. 12, no. 4, pp. 286–293, 2020, [Online]. Available: https://sid.ir/paper/775353/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops