The Effect of Leptin Receptor Gene Polymorphisms (R223Q and P1019P) in Susceptibility to Polycystic Ovarian Syndrome in Kurdish Women

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NASERI ROZITA; Barzin garosi Elahe; SOHRABI MARYAM; Alimoradi Yosra; Cheraghian Fard Mostafa; JALILI CYRUS

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Journal Paper

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Journal: International Journal of Fertility & Sterility Year:2021 | Volume:15 | Issue:2 Page(s): 123-127

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Title

The Effect of Leptin Receptor Gene Polymorphisms (R223Q and P1019P) in Susceptibility to Polycystic Ovarian Syndrome in Kurdish Women

Author(s)

Keywords

Kurdish Population

LEPR

Leptin Receptor

Obesity

Polycystic Ovary Syndrome

Abstract

Background: Polycystic Ovary Syndrome (PCOS) is the known endocrinopathy disorder in the reproductive phase of women’ s life. More than half of the women with PCOS suffer from Obesity which impacts the ovarian functions by leptin levels. Here the R223Q and P1019P polymorphisms of Leptin Receptor (LEPR) gene were examined in PCOS patients of Kurdish women from west of Iran. Materials and Methods: In this case-control study, one hundred women with PCOS and 100 healthy women bearing similar age range were selected based on Rotterdam diagnostic criteria. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to genotype polymorphisms LEPR (R223Q and P1019P), by respectively the BsaWI and NcoI restriction enzymes. Pearson’ s chi-square (χ 2 ) test was used to analyze the variation in genetic distributions and unconditional logistic regression model was used to calculate the odds ratio (OR; 95% CI). Results: Genotype frequencies of the R223Q and P1019P polymorphisms showed significant difference between the patients with PCOS compared to the controls. G allele (R223Q) reduced the risk of PCOS about 0. 49-fold (P<0. 001). While, T allele (P1019P) increased the risk of PCOS 2. 69-fold (P<0. 001). Conclusion: It can be concluded that the R223Q and P1019P polymorphisms showed a significant association with PCOS susceptibility risk. It seems that G allele (R223Q) with reducing OR had a protective effect on this syndrome, while T allele (P1019P) with increasing OR was a risk factor for PCOS.

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APA: Copy

NASERI, ROZITA, Barzin garosi, Elahe, SOHRABI, MARYAM, Alimoradi, Yosra, Cheraghian Fard, Mostafa, & JALILI, CYRUS. (2021). The Effect of Leptin Receptor Gene Polymorphisms (R223Q and P1019P) in Susceptibility to Polycystic Ovarian Syndrome in Kurdish Women. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 15(2), 123-127. SID. https://sid.ir/paper/775530/en

Vancouver: Copy

NASERI ROZITA, Barzin garosi Elahe, SOHRABI MARYAM, Alimoradi Yosra, Cheraghian Fard Mostafa, JALILI CYRUS. The Effect of Leptin Receptor Gene Polymorphisms (R223Q and P1019P) in Susceptibility to Polycystic Ovarian Syndrome in Kurdish Women. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2021;15(2):123-127. Available from: https://sid.ir/paper/775530/en

IEEE: Copy

ROZITA NASERI, Elahe Barzin garosi, MARYAM SOHRABI, Yosra Alimoradi, Mostafa Cheraghian Fard, and CYRUS JALILI, “The Effect of Leptin Receptor Gene Polymorphisms (R223Q and P1019P) in Susceptibility to Polycystic Ovarian Syndrome in Kurdish Women,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 15, no. 2, pp. 123–127, 2021, [Online]. Available: https://sid.ir/paper/775530/en

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