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Title

Evaluation of inflammatory miRNA155 and 146a expression in heart tissue of ovalbumin-sensitized male rats

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Abstract

 Introduction: Asthma is a chronic pulmonary inflammation occurred in response to different allergens, leading to respiratory system insufficiency. The production of different inflammatory factors and enhanced immune system response may affect the function of other organs. The aim of this study was to investigate the expression of inflammatory microRNAs in cardiac tissue in Asthmatic rat models. Methods: In this study, the animals were allocated into control and Asthmatic rats (n=8). To induce Asthma, rats were challenged with ovalbumin (OVA). Fourteen days after induction of Asthma, rats were euthanized and hematoxylin-eosin (H&E) staining was performed to assess pathological changes in their pulmonary tissue. Serum levels of cardiac enzymes were measured using ELISA kits. Finally, transcription level of Inflammatory miRNAs, miRNA-146a and-155, were measured using real-time polymerase chain reaction (PCR) analysis. Results: Based on our findings, histological examination indicated the existence of pathological changes in pulmonary tissue after Asthma induction. Bright-field analysis revealed an existence of inflammatory response and cytotoxicity in cardiac tissue. Also, the serum levels of creatine phosphokinase-MB (CpK-MB), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were significantly higher in the serum of Asthmatic group compared to control group (P < 0. 05). Finally, Asthmatic condition induced the expression of (2-fold) miRNA-146a and (1. 5-fold)-155 in cardiac tissue, respectively. Conclusion: As a conclusion, it could be concluded that Asthmatic condition induces systemic inflammation in cardiac tissue. On a more general note, we propose that therapeutical approaches directed to inflammatory pathway may be required to preserve cardiac injuries caused of Asthma.

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    APA: Copy

    DARBIN, AKBAR, KEYHANMANESH, RANA, AHMADI, MAHDI, & RAHBARGHAZI, REZA. (2021). Evaluation of inflammatory miRNA155 and 146a expression in heart tissue of ovalbumin-sensitized male rats. JOURNAL OF RESEARCH IN CLINICAL MEDICINE, 9(1), 0-0. SID. https://sid.ir/paper/775869/en

    Vancouver: Copy

    DARBIN AKBAR, KEYHANMANESH RANA, AHMADI MAHDI, RAHBARGHAZI REZA. Evaluation of inflammatory miRNA155 and 146a expression in heart tissue of ovalbumin-sensitized male rats. JOURNAL OF RESEARCH IN CLINICAL MEDICINE[Internet]. 2021;9(1):0-0. Available from: https://sid.ir/paper/775869/en

    IEEE: Copy

    AKBAR DARBIN, RANA KEYHANMANESH, MAHDI AHMADI, and REZA RAHBARGHAZI, “Evaluation of inflammatory miRNA155 and 146a expression in heart tissue of ovalbumin-sensitized male rats,” JOURNAL OF RESEARCH IN CLINICAL MEDICINE, vol. 9, no. 1, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/775869/en

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