Prevalence of calreticulin exon 9 mutation in Iranian population with cardiovascular disease

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Mohammad Taghi Zade Mohammad Javad; SAKI NAJMALDIN; HEYBAR HABIB

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF RESEARCH IN CLINICAL MEDICINE Year:2021 | Volume:9 | Issue:1 Page(s): 0-0

Download Full-Text

View:

106

Download:

111

Cites:

Information Journal Paper

Title

Prevalence of calreticulin exon 9 mutation in Iranian population with cardiovascular disease

Author(s)

Mohammad Taghi Zade Mohammad Javad | SAKI NAJMALDIN | HEYBAR HABIB | Issue Writer Certificate

Keywords

Calreticulin

Cardiovascular disease

Coronary angiography

Peripheral arterial disease

Mutation

Abstract

Introduction: Calreticulin (CALR) is a 46 kDa protein in the endoplasmic reticulum and is one of the major proteins in ca2+ binding; it has a key role in oxidative stress, transcription factor activation, and as a chaperone in newly synthesized protein and glycoprotein folding. The high expression of CALR is pivotal for cardiac development in the embryonic period. It has been showed that Mutation in exon 9 of CALR causes loss of C-terminal function and contributes to Cardiovascular disease (CVD) development. It could conceivably be hypothesized that in addition to the general risk factors, the specific gene defects which are less considered can contribute to CVD development. In this regard, this study determined the possible existence of CALR Mutations in CVD development in patients younger than 40. Methods: Thirty patients younger than 40 were recruited for this study, 86. 7% (26) were male, and just 13. 3% (4) were female. The amplification refractory Mutation system-polymerase chain reaction (ARMS-PCR) was used to identify Mutation in exon 9. The CVD risk factors, including blood pressure, type 2 diabetes, dyslipidemia, history of smoking, alcohol drinking, and familial CVD development were evaluated. Results: In none of the patients, CALR Mutations were detected. Since CALR defect causes accumulation of glycogen in the heart’ s cells and contributes to CVD development, our results confirm this, so that 76. 7% of patients did not have diabetes. Conclusion: The findings of the current study show there is no significant differences between exon 9 CALR Mutation and CVD development.

Cites

No record.

References

Cite

APA: Copy

Mohammad Taghi Zade, Mohammad Javad, SAKI, NAJMALDIN, & HEYBAR, HABIB. (2021). Prevalence of calreticulin exon 9 mutation in Iranian population with cardiovascular disease. JOURNAL OF RESEARCH IN CLINICAL MEDICINE, 9(1), 0-0. SID. https://sid.ir/paper/775871/en

Vancouver: Copy

Mohammad Taghi Zade Mohammad Javad, SAKI NAJMALDIN, HEYBAR HABIB. Prevalence of calreticulin exon 9 mutation in Iranian population with cardiovascular disease. JOURNAL OF RESEARCH IN CLINICAL MEDICINE[Internet]. 2021;9(1):0-0. Available from: https://sid.ir/paper/775871/en

IEEE: Copy

Mohammad Javad Mohammad Taghi Zade, NAJMALDIN SAKI, and HABIB HEYBAR, “Prevalence of calreticulin exon 9 mutation in Iranian population with cardiovascular disease,” JOURNAL OF RESEARCH IN CLINICAL MEDICINE, vol. 9, no. 1, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/775871/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops