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Information Journal Paper

Title

Prevention of Corneal Neovascularization; a Preliminary Experimental Study in Rabbits

Pages

  47-55

Abstract

 The purpose of this study was to compare the effects of Propranolol, Timolol and Bevacizumab with Betamethasone to prevent Corneal Neovascularization (CNV) in rabbits. This study was performed on 28 male rabbits. CNV was induced by three 7-0 silk sutures 2 mm long and 1 mm distal to the limbus. Animals were randomly divided into 4 groups of Propranolol + Betamethasone, Timolol + Betamethasone and Bevacizumab + Betamethasone and Betamethasone alone. Eye drops were started from the first day of study. On 7th, 14th, 21st, 28th, 35th and 42nd days, vascular progression, time of neovascularization and vascular area were evaluated and compared with the control group (Betamethasone alone). There was a significant reduction in the area of neovascularization in the Timolol and Bevacizumab groups compared to the control group (P-value = 0. 05, P=0. 047, respectively). Also, regarding vascular progression, there was a significant decrease in the Timolol and Bevacizumab groups (P-value = 0. 014, P=0. 002, respectively). Regarding delayed onset of neovascularization, there was a significant difference in the Timolol and Bevacizumab group in rabbits (P-value = 0. 04, P=0. 00, respectively). In conclusion, the use of Timolol and Bevacizumab drops besides Betamethasone can delay neovascularization and decrease the length of corneal vascularization in rabbits...

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    APA: Copy

    KASIRI, ALI, Mirdehghan, Mohammad Sadegh, FARRAHI, FEREYDOUN, OSTADIAN, FARSHAD, FEGHHI, MOSTAFA, Ghomi, Mehdi Reza, Jafari, Aram Mohammad, MAHDIAN RAD, Atefeh, & KASIRI, NIUSHA. (2020). Prevention of Corneal Neovascularization; a Preliminary Experimental Study in Rabbits. MEDICAL HYPOTHESIS, DISCOVERY AND INNOVATION OPHTHALMOLOGY, 9(1), 47-55. SID. https://sid.ir/paper/775943/en

    Vancouver: Copy

    KASIRI ALI, Mirdehghan Mohammad Sadegh, FARRAHI FEREYDOUN, OSTADIAN FARSHAD, FEGHHI MOSTAFA, Ghomi Mehdi Reza, Jafari Aram Mohammad, MAHDIAN RAD Atefeh, KASIRI NIUSHA. Prevention of Corneal Neovascularization; a Preliminary Experimental Study in Rabbits. MEDICAL HYPOTHESIS, DISCOVERY AND INNOVATION OPHTHALMOLOGY[Internet]. 2020;9(1):47-55. Available from: https://sid.ir/paper/775943/en

    IEEE: Copy

    ALI KASIRI, Mohammad Sadegh Mirdehghan, FEREYDOUN FARRAHI, FARSHAD OSTADIAN, MOSTAFA FEGHHI, Mehdi Reza Ghomi, Aram Mohammad Jafari, Atefeh MAHDIAN RAD, and NIUSHA KASIRI, “Prevention of Corneal Neovascularization; a Preliminary Experimental Study in Rabbits,” MEDICAL HYPOTHESIS, DISCOVERY AND INNOVATION OPHTHALMOLOGY, vol. 9, no. 1, pp. 47–55, 2020, [Online]. Available: https://sid.ir/paper/775943/en

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