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Information Journal Paper

Title

Isolation of Candida africana in oral candidiasis: First report among cancer patients in Iran

Pages

  58-62

Abstract

 Background and Purpose: Oropharyngeal candidiasis (OPC) is a fungal infection of the oral cavity caused by the members of C. albicans complex. Although C. africana, as a part of the complex, is considered to be mostly responsible for the development of vulvovaginal candidiasis, it may be associated with a wider clinical spectrum. Case report: This report described two cases diagnosed with Oral candidiasis during the receipt of treatment for malignancies. Conventional and molecular tests were performed on the samples collected from the patients’ oral cavities. The test results revealed C. africana as the causative agent of Oral candidiasis. Furthermore, in vitro antifungal susceptibility test indicated the full susceptibility of all C. africana isolates to caspofungin. However, the data were also suggestive of the resistance against fluconazole and amphotericin B. Caspofungin was used as the main antifungal agent for the treatment of Oral candidiasis, resulting in the improvement of thrush in patients. The resistance of C. africana to fluconazole and amphotericin B suggests the necessity of performing in vitro susceptibility testing on the isolates for the selection of appropriate antifungal agents. Conclusion: As the findings indicated, the achievement of knowledge regarding C. africana as an emerging non-albicans Candida species and its antifungal susceptibility profile is crucial to select antifungal prophylaxis and empirical therapy for Oral candidiasis in Cancer patients undergoing chemotherapy.

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    APA: Copy

    LOTFALI, ENSIEH, MARDANI, MASOUD, ABOLGHASEMI, SARA, Darvishnia, David, Rabiei, Mohammad Mahdi, GHASEMI, REZA, & Fattahi, Azam. (2020). Isolation of Candida africana in oral candidiasis: First report among cancer patients in Iran. CURRENT MEDICAL MYCOLOGY, 6(2), 58-62. SID. https://sid.ir/paper/776618/en

    Vancouver: Copy

    LOTFALI ENSIEH, MARDANI MASOUD, ABOLGHASEMI SARA, Darvishnia David, Rabiei Mohammad Mahdi, GHASEMI REZA, Fattahi Azam. Isolation of Candida africana in oral candidiasis: First report among cancer patients in Iran. CURRENT MEDICAL MYCOLOGY[Internet]. 2020;6(2):58-62. Available from: https://sid.ir/paper/776618/en

    IEEE: Copy

    ENSIEH LOTFALI, MASOUD MARDANI, SARA ABOLGHASEMI, David Darvishnia, Mohammad Mahdi Rabiei, REZA GHASEMI, and Azam Fattahi, “Isolation of Candida africana in oral candidiasis: First report among cancer patients in Iran,” CURRENT MEDICAL MYCOLOGY, vol. 6, no. 2, pp. 58–62, 2020, [Online]. Available: https://sid.ir/paper/776618/en

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