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Information Journal Paper

Title

Systemic Immunosuppression for Limbal Allograft and Allogenic Limbal Epithelial Cell Transplantation

Pages

  23-32

Abstract

 Bilateral Limbal Stem Cell Deficiency (LSCD) treatment requires the need to obtain allogenic limbal tissue for transplantation. Outcomes of different surgical techniques depend on multiple factors, including the underlying etiology, ocular surface, eyelid status and used surgical intervention. Some of the management options for bilateral LSCD include cadaveric, living related or living non-related conjunctival Limbal Allograft (CLAL), keratoLimbal Allograft (KLAL), allogenic cultured limbal epithelial transplantation (CLET) and allogenic simple limbal epithelial transplantation (SLET). Systemic Immunosuppressive Therapy plays a pivotal role in survival of transplanted tissue. The present review focuses on different systemic immunosuppression protocols for Limbal Allograft and allogenic Limbal Epithelial Cell transplantation, with specific emphasis on different surgical techniques and their outcomes. We included all reports with details of different systemic immunosuppression protocols for Limbal Allograft and allogenic Limbal Epithelial Cell transplantation. Oral cyclosporine A at different doses is the most commonly used immunosuppressive agent in Limbal Allograft and allogenic Limbal Epithelial Cell transplantation. However, different studies using oral mycophenolate mofetil and tacrolimus also reported good results. In conclusion, systemic immunosuppression protocols for Limbal Allograft and allogenic Limbal Epithelial Cell transplantation are not standardized. Further studies regarding different surgical techniques should assess outcomes and adverse effects of such protocols...

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    Cite

    APA: Copy

    Carlos Serna Ojeda, Juan, Basu, Sayan, Vazirani, Jayesh, Garfias, Yonathan, & S.Sangwan, Virender. (2020). Systemic Immunosuppression for Limbal Allograft and Allogenic Limbal Epithelial Cell Transplantation. MEDICAL HYPOTHESIS, DISCOVERY AND INNOVATION OPHTHALMOLOGY, 9(1), 23-32. SID. https://sid.ir/paper/777309/en

    Vancouver: Copy

    Carlos Serna Ojeda Juan, Basu Sayan, Vazirani Jayesh, Garfias Yonathan, S.Sangwan Virender. Systemic Immunosuppression for Limbal Allograft and Allogenic Limbal Epithelial Cell Transplantation. MEDICAL HYPOTHESIS, DISCOVERY AND INNOVATION OPHTHALMOLOGY[Internet]. 2020;9(1):23-32. Available from: https://sid.ir/paper/777309/en

    IEEE: Copy

    Juan Carlos Serna Ojeda, Sayan Basu, Jayesh Vazirani, Yonathan Garfias, and Virender S.Sangwan, “Systemic Immunosuppression for Limbal Allograft and Allogenic Limbal Epithelial Cell Transplantation,” MEDICAL HYPOTHESIS, DISCOVERY AND INNOVATION OPHTHALMOLOGY, vol. 9, no. 1, pp. 23–32, 2020, [Online]. Available: https://sid.ir/paper/777309/en

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