Simultaneous Effects of Aerobic Training and Berberine Chloride on Plasma Glucose, IL-6 and TNF-α in Type 1 Diabetic Male Wistar Rats

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RAMEZANI JAVAD; AZARBAYJANI MOHAMMAD ALI; PEERI MAGHSOUD

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Journal Paper

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Journal: NUTRITION AND FOOD SCIENCES RESEARCH Year:2019 | Volume:6 | Issue:1 Page(s): 9-16

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Title

Simultaneous Effects of Aerobic Training and Berberine Chloride on Plasma Glucose, IL-6 and TNF-α in Type 1 Diabetic Male Wistar Rats

Author(s)

RAMEZANI JAVAD | AZARBAYJANI MOHAMMAD ALI | PEERI MAGHSOUD | Issue Writer Certificate

Keywords

Type 1 Diabetes

Aerobic training

Berberine chloride

IL-6

TNF-α

Abstract

Background and Objectives: Aerobic training and Berberine chloride include antioxidant and anti-inflammatory characteristics. In the current study, simultaneous effects of Aerobic training and Berberine chloride on plasma glucose, IL-6 and TNF-α were investigated in type 1 diabetic male Wistar rats. Materials and Methods: In this experimental study, 64 male Wistar rats were randomly divided into eight groups (n=8), including healthy control, diabetic control, diabetic-berberine (15 and 30 mg/kg), diabetic-training, diabetictraining-berberine (15 and 30 mg/kg) and health-trained. Diabetes was induced using a single intraperitoneal injection (IP) of streptozotocin (STZ) of 60 mg/kg body weight (BW). The training schedule included running on a treadmill for six weeks, five sessions a week and daily intakes of berberine using gavage. The IL-6 and TNF-α values were assessed using enzyme-linked immunosorbent assay (ELISA) method. Results: Results showed that the glucose concentration in diabetic groups with Aerobic training and intake of berberine simultaneously was significantly lower than that in the diabetic control group (P<0. 05). Plasma IL-6 in the diabetic control group significantly increased, compared to that in the normal control group (P<0. 05). In diabetic groups that received the two treatments simultaneously, IL-6 significantly increased, compared to that in the diabetic control group (P<0. 05). The quantity of TNF-α in the diabetic control group was significantly higher than that in the normal control group (P<0. 05). The plasma level of TNF-α significantly decreased in all treatment groups, compared to that in the diabetic control group (P<0. 05). Conclusions: Combined effects of Berberine chloride use and Aerobic training on blood glucose, IL-6 and TNF-α are more evident than their individual effects. Furthermore, a dose of 30 mg/kg of Berberine chloride included a greater effect on the highlighted blood parameters, compared to that a dose of 15 mg/kg of Berberine chloride did.

Cites

Response of Some Apoptotic Indices to Six Weeks of Aerobic Training in Streptozotocin-Induced Diabetic Rats

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APA: Copy

RAMEZANI, JAVAD, AZARBAYJANI, MOHAMMAD ALI, & PEERI, MAGHSOUD. (2019). Simultaneous Effects of Aerobic Training and Berberine Chloride on Plasma Glucose, IL-6 and TNF-α in Type 1 Diabetic Male Wistar Rats. NUTRITION AND FOOD SCIENCES RESEARCH, 6(1), 9-16. SID. https://sid.ir/paper/777334/en

Vancouver: Copy

RAMEZANI JAVAD, AZARBAYJANI MOHAMMAD ALI, PEERI MAGHSOUD. Simultaneous Effects of Aerobic Training and Berberine Chloride on Plasma Glucose, IL-6 and TNF-α in Type 1 Diabetic Male Wistar Rats. NUTRITION AND FOOD SCIENCES RESEARCH[Internet]. 2019;6(1):9-16. Available from: https://sid.ir/paper/777334/en

IEEE: Copy

JAVAD RAMEZANI, MOHAMMAD ALI AZARBAYJANI, and MAGHSOUD PEERI, “Simultaneous Effects of Aerobic Training and Berberine Chloride on Plasma Glucose, IL-6 and TNF-α in Type 1 Diabetic Male Wistar Rats,” NUTRITION AND FOOD SCIENCES RESEARCH, vol. 6, no. 1, pp. 9–16, 2019, [Online]. Available: https://sid.ir/paper/777334/en

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