Determination of Factors Affecting Bivalent (Type 1 and 3) Stability of Oral Poliomyelitis Vaccine

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SOLEIMANI SINA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: MEDICAL LABORATORY JOURNAL Year:2020 | Volume:14 | Issue:1 Page(s): 36-43

Download Full-Text

View:

139

Download:

Cites:

Information Journal Paper

Title

Determination of Factors Affecting Bivalent (Type 1 and 3) Stability of Oral Poliomyelitis Vaccine

Author(s)

SOLEIMANI SINA | Issue Writer Certificate

Keywords

Poliovirus vaccine

Refrigeration

Temperature

Freezing

Vaccine potency

Iran

Immunization programs

Vaccination

Protein stability

Abstract

Background and Objectives: In recent years, due to the eradication of type 2 poliovirus, a bivalent vaccine containing types 1 and 3 is used in Iran. Since it is a highly thermolabile vaccine, it should be stored at a recommended Temperature. Since cold chain may not be applied in Iran’ s tropical weather conditions, potency of the vaccine may be subjected to change. Therefore, we evaluated the effective factors on the potency of this vaccine. Methods: We evaluated stability of a bivalent oral Poliovirus vaccine produced by Razi Institute of Iran to ensure consistency of virus at different Temperatures (-20, 2-8, 22-25 and 35-37 º C), time intervals and freeze/thaw cycles. Three consecutive batches produced during full-scale production were randomly sampled. Results: At-20 oC, there was no change in vaccine vial monitor (VVM). The potency of the samples exposed to 2-8 oC for 60 days and to 22-25 oC for five days met the specification. The mean potency of the samples was 6. 17, 6. 00, 5. 83, 5. 75 and 5. 54 (log CCID50/dose) after 10, 20, 30, 40 and 50 freeze/thaw cycles, respectively. In addition, the mean degradation of VVM was 0, 23. 33, 60 and 100% for samples exposed to-20, 2-8, 22-25 and 35-37 oC, respectively. Conclusion: The results indicate the effects of environmental factors on the potency of the vaccines and the correlation between the VVM grade, color change and the Vaccine potency for programming vaccine distribution networks at different transit levels. Based on the results of our study, the best Temperature for maintenance and transportation of bivalent oral Poliovirus vaccine is-20 oC. Furthermore, freeze/thaw cycles lower the potency of the vaccine and change the VVM grade significantly.

Cites

No record.

References

Cite

APA: Copy

SOLEIMANI, SINA. (2020). Determination of Factors Affecting Bivalent (Type 1 and 3) Stability of Oral Poliomyelitis Vaccine. MEDICAL LABORATORY JOURNAL, 14(1), 36-43. SID. https://sid.ir/paper/777591/en

Vancouver: Copy

SOLEIMANI SINA. Determination of Factors Affecting Bivalent (Type 1 and 3) Stability of Oral Poliomyelitis Vaccine. MEDICAL LABORATORY JOURNAL[Internet]. 2020;14(1):36-43. Available from: https://sid.ir/paper/777591/en

IEEE: Copy

SINA SOLEIMANI, “Determination of Factors Affecting Bivalent (Type 1 and 3) Stability of Oral Poliomyelitis Vaccine,” MEDICAL LABORATORY JOURNAL, vol. 14, no. 1, pp. 36–43, 2020, [Online]. Available: https://sid.ir/paper/777591/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops