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Information Journal Paper

Title

The Antiangiogenic Properties of Adipose-Derived Mesenchymal Stem/Stromal Cells in Corneal Neovascularization in a Rabbit Model

Pages

  74-84

Abstract

 The purpose was to study the anti-angiogenic effect of adipose-derived mesenchymal stem/stromal cells (ADMSCs) on experimentally induced corneal injuries. Corneal Neovascularization (NV) was induced by incising and subsequently suturing the corneal surface in 32 New Zealand rabbits. Following suturing, the rabbits were randomly allocated into 2 groups, and received either phosphate-buffered saline (PBS) (control) or ADMSCs, both administered via three different routes. Digital images of the cornea were obtained two weeks post-incision to measure the area of neovascularized cornea. Tumor necrosis factor (TNF) was immunohistochemically assessed in the both groups. The corneal tissue was evaluated for vascular endothelial growth factor (VEGF). The extent of corneal NV in all eyes was assessed photographically by an independent observer. Fourteen days after the incisions, the degree of corneal NV was substantially decreased in the ADMSC-treated group (1. 87 ± 0. 9 mm2, 1. 4 % ± 0. 67 % of corneal surface) compared to the control and PBS-treated group (4. 66 ± 1. 74 mm2, 3. 51 % ± 1. 31 %, p < 0. 001). ADMSCs significantly decreased injury-induced corneal NV in New Zealand rabbits two weeks post-treatment. This strategy has potential for use in the control of corneal NV in vivo...

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    APA: Copy

    Pirounides, Demetrios, Komnenou, Anastasia, Papaioannou, Nikolaos, Gounari, Eleni, Stylianaki, Ioanna, Alexandridis, Alexandros, Chranioti, Angeliki, Kofidou, Evangelia, Koliakos, Georgios, & Karampatakis, Vasileios. (2020). The Antiangiogenic Properties of Adipose-Derived Mesenchymal Stem/Stromal Cells in Corneal Neovascularization in a Rabbit Model. MEDICAL HYPOTHESIS, DISCOVERY AND INNOVATION OPHTHALMOLOGY, 9(2), 74-84. SID. https://sid.ir/paper/777615/en

    Vancouver: Copy

    Pirounides Demetrios, Komnenou Anastasia, Papaioannou Nikolaos, Gounari Eleni, Stylianaki Ioanna, Alexandridis Alexandros, Chranioti Angeliki, Kofidou Evangelia, Koliakos Georgios, Karampatakis Vasileios. The Antiangiogenic Properties of Adipose-Derived Mesenchymal Stem/Stromal Cells in Corneal Neovascularization in a Rabbit Model. MEDICAL HYPOTHESIS, DISCOVERY AND INNOVATION OPHTHALMOLOGY[Internet]. 2020;9(2):74-84. Available from: https://sid.ir/paper/777615/en

    IEEE: Copy

    Demetrios Pirounides, Anastasia Komnenou, Nikolaos Papaioannou, Eleni Gounari, Ioanna Stylianaki, Alexandros Alexandridis, Angeliki Chranioti, Evangelia Kofidou, Georgios Koliakos, and Vasileios Karampatakis, “The Antiangiogenic Properties of Adipose-Derived Mesenchymal Stem/Stromal Cells in Corneal Neovascularization in a Rabbit Model,” MEDICAL HYPOTHESIS, DISCOVERY AND INNOVATION OPHTHALMOLOGY, vol. 9, no. 2, pp. 74–84, 2020, [Online]. Available: https://sid.ir/paper/777615/en

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