The Efficacy of Paricalcitol Administration for Management of Pediatric Chronic Kidney Disease: A Systematic Review and Meta-analysis

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FAZEL MOJTABA; Khari Sorour; IMGubari Mohammed; ATAEI NEAMATOLLAH; YOUSEFIFARD MAHMOUD; HOSSEINI MOSTAFA

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Journal: Journal of Pediatric Perspectives Year:2020 | Volume:8 | Issue:2 (74) Page(s): 10951-10959

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Title

The Efficacy of Paricalcitol Administration for Management of Pediatric Chronic Kidney Disease: A Systematic Review and Meta-analysis

Author(s)

Keywords

Chronic Kidney disease

Chronic

Paricalcitol

Renal Insufficiency

Vitamin D

Abstract

Background: There is still controversy about the efficacy of Paricalcitol in children with Chronic Kidney disease/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">Chronic Kidney disease (CKD). Therefore, the present study was designed to assess current evidence on the efficacy of Paricalcitol in CKD children. Materials and Methods: In this systematic review, an extensive search was performed on the databases of Medline, Embase, Scopus and Web of Science up to the end of October 2019. The keywords related to CKD and Paricalcitol were combined and searched. Two independent researchers reviewed the papers; data were analyzed in STATA 14. 0 statistical program and the effect of Paricalcitol administration on serum levels of intact parathyroid hormone (iPTH), calcium (Ca), phosphorous (P), and Ca × P product ratio were reported as odds ratio (OR), and 95% confidence interval (95%CI). Results: Finally, data from three studies were included in the present study. Paricalcitol administration decreased iPTH levels in children with CKD (OR=0. 12; 95%CI: 0. 05 to 0. 29; p<0. 001). However, Paricalcitol administration had no effect on serum calcium level (OR=1. 16; 95%CI: 0. 48 to 2. 80; p=0. 741), serum phosphorus level (OR=0. 87; 95%CI: 0. 38 to 1. 99; p=0. 735), and Ca × P ratio (OR=0. 48; 95% CI: 0. 15 to 1. 50; p=0. 208). No study has investigated the efficacy of Paricalcitol on the control of proteinuria following CKD. Conclusion: There is limited evidence on the efficacy and safety of Paricalcitol in children with CKD. There are no studies in CKD children that have shown efficacy of Paricalcitol in controlling proteinuria.

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APA: Copy

FAZEL, MOJTABA, Khari, Sorour, IMGubari, Mohammed, ATAEI, NEAMATOLLAH, YOUSEFIFARD, MAHMOUD, & HOSSEINI, MOSTAFA. (2020). The Efficacy of Paricalcitol Administration for Management of Pediatric Chronic Kidney Disease: A Systematic Review and Meta-analysis. INTERNATIONAL JOURNAL OF PEDIATRICS, 8(2 (74)), 10951-10959. SID. https://sid.ir/paper/777874/en

Vancouver: Copy

FAZEL MOJTABA, Khari Sorour, IMGubari Mohammed, ATAEI NEAMATOLLAH, YOUSEFIFARD MAHMOUD, HOSSEINI MOSTAFA. The Efficacy of Paricalcitol Administration for Management of Pediatric Chronic Kidney Disease: A Systematic Review and Meta-analysis. INTERNATIONAL JOURNAL OF PEDIATRICS[Internet]. 2020;8(2 (74)):10951-10959. Available from: https://sid.ir/paper/777874/en

IEEE: Copy

MOJTABA FAZEL, Sorour Khari, Mohammed IMGubari, NEAMATOLLAH ATAEI, MAHMOUD YOUSEFIFARD, and MOSTAFA HOSSEINI, “The Efficacy of Paricalcitol Administration for Management of Pediatric Chronic Kidney Disease: A Systematic Review and Meta-analysis,” INTERNATIONAL JOURNAL OF PEDIATRICS, vol. 8, no. 2 (74), pp. 10951–10959, 2020, [Online]. Available: https://sid.ir/paper/777874/en

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