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Information Journal Paper

Title

The Synergistic Effect of Co-delivery of Anticancer Drugs Into Astrocytes Isolated From Human Glioblastoma Multiforme

Pages

  185-189

Abstract

 Background: Chemotherapy drugs are not effective in the treatment of primary brain tumors due to the low efficacy of these drugs and drug transfer from the blood-brain barrier (BBB) toward the tumor site. Our purpose in this study was to assess the co-delivery of Anticancer drugs to increase drug permeability from BBB. Methods: In this study, two chemotherapy drugs, namely Methotrexate (MTX) and Paclitaxel (PTX), were inserted into polyvinyl alcohol and poloxamer188-conjugated nanoparticles (NPs). Astrocytes were treated with different concentrations of 0-50 μ g/ml from MTX, PTX, the MTX-PTX mixture, PTX-loaded NPs, MTX-loaded NPs, and PTX-MTX co-loaded NPs for 48 hours. The tumoricidal effect was assessed using the survival rate, Hoechst staining, and western blotting. Results: The results indicated significant reduction of the survival rate in astrocytes treated with PTX-MTX co-loaded NPs. In addition, Apoptosis hallmarks consisting of fragmented DNA, overexpression of Bax, and expression reduction of Bcl-2 were in the cultured astrocytes. Conclusions: Our study proposes that the PTX-MTX co-delivery to NPs could be used as a possible approach for anti-cancer drug delivery to Glioblastoma multiforme.

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    APA: Copy

    HASHEMI, MANSOUREH, & ZALI, ALIREZA. (2020). The Synergistic Effect of Co-delivery of Anticancer Drugs Into Astrocytes Isolated From Human Glioblastoma Multiforme. INTERNATIONAL CLINICAL NEUROSCIENCE JOURNAL, 7(4), 185-189. SID. https://sid.ir/paper/778710/en

    Vancouver: Copy

    HASHEMI MANSOUREH, ZALI ALIREZA. The Synergistic Effect of Co-delivery of Anticancer Drugs Into Astrocytes Isolated From Human Glioblastoma Multiforme. INTERNATIONAL CLINICAL NEUROSCIENCE JOURNAL[Internet]. 2020;7(4):185-189. Available from: https://sid.ir/paper/778710/en

    IEEE: Copy

    MANSOUREH HASHEMI, and ALIREZA ZALI, “The Synergistic Effect of Co-delivery of Anticancer Drugs Into Astrocytes Isolated From Human Glioblastoma Multiforme,” INTERNATIONAL CLINICAL NEUROSCIENCE JOURNAL, vol. 7, no. 4, pp. 185–189, 2020, [Online]. Available: https://sid.ir/paper/778710/en

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