THE EFFECTS OF HYDRO ALCOHOLIC EXTRACT OF DOREMA AUCHERI ON BLOOD CONCENTRATION OF GONADOTROPIN AND ANDROGEN HORMONES IN ADULT MALE RATS

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AZARNIOUSHAN F.; KHATAMSAZ S.; SADEGHI HEYBAT ELAH

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Journal: Armaghane Danesh Year:2009 | Volume:14 | Issue:3 (55) Page(s): 63-70

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Title

THE EFFECTS OF HYDRO ALCOHOLIC EXTRACT OF DOREMA AUCHERI ON BLOOD CONCENTRATION OF GONADOTROPIN AND ANDROGEN HORMONES IN ADULT MALE RATS

Author(s)

AZARNIOUSHAN F. | KHATAMSAZ S. | SADEGHI HEYBAT ELAH | Issue Writer Certificate

Keywords

DOREMA AUCHERI EXTRACTQ2

HPG AXISQ3

SEX HORMONESQ3

TESTOSTERONEQ2

Abstract

Introduction & Objective: Dorema aucheri (Apieaceae) contains chemical compounds including flavonoids and coumarins.Flavonoids have estrogenic properties and coumarins have antiandrogenic properties. The compounds are very effective on the HPG AXIS. In the present study, the effect of Dorema aucheri alcoholic extract on LH, FSH, TESTOSTERONE and DHT hormones on adult male rats were determined.Materials & Methods: This was an experimental study in which male adult rats were chosen and divided into 5 groups: control group which did not received any extract, sham groups which took distilled water, experimental groups, which orally took 100, 200 and 400 mg per kg of the DOREMA AUCHERI EXTRACT for 28 consecutive days. Then the animals were weighed and the blood sample of each group was taken and used for measuring of the serum concentration of FSH, LH, DHT and TESTOSTERONE. The collected data were analyzed by the SPSS software using ANOVA and ttest.Result: The results revealed no differences in the average weight of the body and concentration of FSH hormone in the experimental group compared with the control and sham group. However significant difference was found between the concentration of LH, TESTOSTERONE and dihydrotestosterone in the experimental group compared with the rest groups. Concentration of TESTOSTERONE in the minimum dosage of extracts showed significant increase while significant decrease was seen in the higher dose. Significant increase was seen in the concentration of LH in all doses. DHT serum concentration in the minimum dose showed significant decrease while significant increase was seen in higher dosage.Conclusion: It seems that the flavonoids compound of DOREMA AUCHERI EXTRACT caused the LH hormone to increase prolactin.Using the extract increases the LH hormone and inhibition of aromatase and 5 alfa reductase enzymes cause the TESTOSTERONE and DHT hormone to increase in higher dosage.

Cites

ASSESSMENT OF PHYTOCHEMICAL, MORPHOLOGICAL AND ANTIOXIDANT VARIATION OF BILEHAR (DOREMA AUCHERI) POPULATIONS CULTIVATED IN DIFFERENT ENVIRONMENTAL CONDITIONS

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APA: Copy

AZARNIOUSHAN, F., KHATAMSAZ, S., & SADEGHI, HEYBAT ELAH. (2009). THE EFFECTS OF HYDRO ALCOHOLIC EXTRACT OF DOREMA AUCHERI ON BLOOD CONCENTRATION OF GONADOTROPIN AND ANDROGEN HORMONES IN ADULT MALE RATS. ARMAGHAN DANESH, 14(3 (55)), 63-70. SID. https://sid.ir/paper/78024/en

Vancouver: Copy

AZARNIOUSHAN F., KHATAMSAZ S., SADEGHI HEYBAT ELAH. THE EFFECTS OF HYDRO ALCOHOLIC EXTRACT OF DOREMA AUCHERI ON BLOOD CONCENTRATION OF GONADOTROPIN AND ANDROGEN HORMONES IN ADULT MALE RATS. ARMAGHAN DANESH[Internet]. 2009;14(3 (55)):63-70. Available from: https://sid.ir/paper/78024/en

IEEE: Copy

F. AZARNIOUSHAN, S. KHATAMSAZ, and HEYBAT ELAH SADEGHI, “THE EFFECTS OF HYDRO ALCOHOLIC EXTRACT OF DOREMA AUCHERI ON BLOOD CONCENTRATION OF GONADOTROPIN AND ANDROGEN HORMONES IN ADULT MALE RATS,” ARMAGHAN DANESH, vol. 14, no. 3 (55), pp. 63–70, 2009, [Online]. Available: https://sid.ir/paper/78024/en

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