Effect of tocopherol on microemulsions: turbidity studies and Dynamic light scattering and dynamic surface tension measurements

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RAHDAR ABBAS

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Journal Paper

Paper Information

Journal: NANOMEDICINE RESEARCH JOURNAL Year:2018 | Volume:3 | Issue:4 Page(s): 206-218

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Title

Effect of tocopherol on microemulsions: turbidity studies and Dynamic light scattering and dynamic surface tension measurements

Author(s)

RAHDAR ABBAS | Issue Writer Certificate

Keywords

F127; Oil-in-water microemulsion; Pluronic; Tocopherol; Turbidity

Abstract

The development and design of the biocompatible and biodegradable thermodynamically stable micellar and microemulsion transparent dispersions to reduce the free and unbounded drugs concentration in the blood is a basic challenge in field of drug efficacy and bioavailability of drugs. In the current work, solubilization capacity of the drug (Tocopherol), oil (Ethyl Butyrate), and oil+drug (1: 1 molar ratio) into F127 pluronic microemulsions was studied as a function of F127 concentration by using turbidity or transparency experiments. F127-based oil-in-water microemulsions with different compositions were synthesized and titrated with drug (Tocopherol), oil (Ethyl Butyrate), and oil+drug (1: 1 molar ratio), separately, to determine clear /turbid transition zone. It was observed that at certain concentration of Pluronic F127, microemulsion samples were gel-like. This specific concentration of F127 was different for three systems mentioned. It also observed that by increasing concentration of fatty acid of sodium caprylate (SC) in the system, solutions became transparent. By the current experiments, it was possible to determine the optimal binding ratio of F127 and/or sodium caprylate to ethyl butyrate oil, Tocopherol drug, and oil+drug (1: 1 molar ratio) in microemulsion. To study the bounding process of the fatty acid to the F127 within microemulsion, the microemulsion formulations were characterized by means of the dynamic surface tension and dynamic light scattering. According to this effort, we have concluded that there are approximately 1 molecule of oil for every 2 molecule of F127 (for system titration with oil), approximately 4 molecules of Tocopherol Drug for every 100 molecule of F127 (for system titration with drug), and approximately 4 molecule from the oil+drug (1: 1 molar ratio) for every 5 molecule of F127 (for system titration with oil+drug (1: 1 molar ratio) in the optimal microemulsion formulation. These results highlight the useful information about the mechanism of binding of the tocopherol, oil, and oil: drug mixture (1: 1 molar ratio) to the F127 microemulsion.

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APA: Copy

RAHDAR, ABBAS. (2018). Effect of tocopherol on microemulsions: turbidity studies and Dynamic light scattering and dynamic surface tension measurements. NANOMEDICINE RESEARCH JOURNAL, 3(4), 206-218. SID. https://sid.ir/paper/780345/en

Vancouver: Copy

RAHDAR ABBAS. Effect of tocopherol on microemulsions: turbidity studies and Dynamic light scattering and dynamic surface tension measurements. NANOMEDICINE RESEARCH JOURNAL[Internet]. 2018;3(4):206-218. Available from: https://sid.ir/paper/780345/en

IEEE: Copy

ABBAS RAHDAR, “Effect of tocopherol on microemulsions: turbidity studies and Dynamic light scattering and dynamic surface tension measurements,” NANOMEDICINE RESEARCH JOURNAL, vol. 3, no. 4, pp. 206–218, 2018, [Online]. Available: https://sid.ir/paper/780345/en

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